Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment?

Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood‐brain barrier and at what extend, especially in reduced doses given for drug‐drug interactions.

Detalles Bibliográficos
Autores principales: Dimou, Maria, Bitsani, Aikaterini, Roumelioti, Maria, Dimitrakopoulou, Aglaia, Iliakis, Theodore, Pardalis, Vasileios, Grafakos, Ioannis, Kalyva, Sotiria, Markopoulos, Athanasios, Kyrtsonis, Marie‐Christine, Panayiotidis, Panayiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077271/
https://www.ncbi.nlm.nih.gov/pubmed/33936674
http://dx.doi.org/10.1002/ccr3.4002
Descripción
Sumario:Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood‐brain barrier and at what extend, especially in reduced doses given for drug‐drug interactions.

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