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Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment?
Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood‐brain barrier and at what extend, especially in reduced doses given for drug‐drug interactions.
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077271/ https://www.ncbi.nlm.nih.gov/pubmed/33936674 http://dx.doi.org/10.1002/ccr3.4002 |
| _version_ | 1783684848551985152 |
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| author | Dimou, Maria Bitsani, Aikaterini Roumelioti, Maria Dimitrakopoulou, Aglaia Iliakis, Theodore Pardalis, Vasileios Grafakos, Ioannis Kalyva, Sotiria Markopoulos, Athanasios Kyrtsonis, Marie‐Christine Panayiotidis, Panayiotis |
| author_facet | Dimou, Maria Bitsani, Aikaterini Roumelioti, Maria Dimitrakopoulou, Aglaia Iliakis, Theodore Pardalis, Vasileios Grafakos, Ioannis Kalyva, Sotiria Markopoulos, Athanasios Kyrtsonis, Marie‐Christine Panayiotidis, Panayiotis |
| author_sort | Dimou, Maria |
| collection | PubMed |
| description | Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood‐brain barrier and at what extend, especially in reduced doses given for drug‐drug interactions. |
| format | Online Article Text |
| id | pubmed-8077271 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-80772712021-04-29 Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment? Dimou, Maria Bitsani, Aikaterini Roumelioti, Maria Dimitrakopoulou, Aglaia Iliakis, Theodore Pardalis, Vasileios Grafakos, Ioannis Kalyva, Sotiria Markopoulos, Athanasios Kyrtsonis, Marie‐Christine Panayiotidis, Panayiotis Clin Case Rep Case Reports Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood‐brain barrier and at what extend, especially in reduced doses given for drug‐drug interactions. John Wiley and Sons Inc. 2021-03-04 /pmc/articles/PMC8077271/ /pubmed/33936674 http://dx.doi.org/10.1002/ccr3.4002 Text en © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| spellingShingle | Case Reports Dimou, Maria Bitsani, Aikaterini Roumelioti, Maria Dimitrakopoulou, Aglaia Iliakis, Theodore Pardalis, Vasileios Grafakos, Ioannis Kalyva, Sotiria Markopoulos, Athanasios Kyrtsonis, Marie‐Christine Panayiotidis, Panayiotis Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment? |
| title | Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment? |
| title_full | Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment? |
| title_fullStr | Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment? |
| title_full_unstemmed | Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment? |
| title_short | Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment? |
| title_sort | richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment? |
| topic | Case Reports |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077271/ https://www.ncbi.nlm.nih.gov/pubmed/33936674 http://dx.doi.org/10.1002/ccr3.4002 |
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