BRAF‐mutated malignant melanoma with chondrosarcomatous differentiation in inguinal nodal metastasis

We report the case of a young woman who developed metastatic melanoma in the inguinal nodal region, which acquired chondrosarcomatous differentiation and preserved the BRAF mutation found in the primary tumor. The patient was treated with a BRAF/MEK inhibitor combination therapy (dabrafenib/trametin...

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Autores principales: Abbati, Francesca, Altimari, Annalisa, Corti, Barbara, Dika, Emi, Sperandi, Francesca, Melotti, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077358/
https://www.ncbi.nlm.nih.gov/pubmed/33936664
http://dx.doi.org/10.1002/ccr3.3982
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author Abbati, Francesca
Altimari, Annalisa
Corti, Barbara
Dika, Emi
Sperandi, Francesca
Melotti, Barbara
author_facet Abbati, Francesca
Altimari, Annalisa
Corti, Barbara
Dika, Emi
Sperandi, Francesca
Melotti, Barbara
author_sort Abbati, Francesca
collection PubMed
description We report the case of a young woman who developed metastatic melanoma in the inguinal nodal region, which acquired chondrosarcomatous differentiation and preserved the BRAF mutation found in the primary tumor. The patient was treated with a BRAF/MEK inhibitor combination therapy (dabrafenib/trametinib), which was demonstrated to be effective and well‐tolerated.
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spelling pubmed-80773582021-04-29 BRAF‐mutated malignant melanoma with chondrosarcomatous differentiation in inguinal nodal metastasis Abbati, Francesca Altimari, Annalisa Corti, Barbara Dika, Emi Sperandi, Francesca Melotti, Barbara Clin Case Rep Case Reports We report the case of a young woman who developed metastatic melanoma in the inguinal nodal region, which acquired chondrosarcomatous differentiation and preserved the BRAF mutation found in the primary tumor. The patient was treated with a BRAF/MEK inhibitor combination therapy (dabrafenib/trametinib), which was demonstrated to be effective and well‐tolerated. John Wiley and Sons Inc. 2021-03-07 /pmc/articles/PMC8077358/ /pubmed/33936664 http://dx.doi.org/10.1002/ccr3.3982 Text en © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Abbati, Francesca
Altimari, Annalisa
Corti, Barbara
Dika, Emi
Sperandi, Francesca
Melotti, Barbara
BRAF‐mutated malignant melanoma with chondrosarcomatous differentiation in inguinal nodal metastasis
title BRAF‐mutated malignant melanoma with chondrosarcomatous differentiation in inguinal nodal metastasis
title_full BRAF‐mutated malignant melanoma with chondrosarcomatous differentiation in inguinal nodal metastasis
title_fullStr BRAF‐mutated malignant melanoma with chondrosarcomatous differentiation in inguinal nodal metastasis
title_full_unstemmed BRAF‐mutated malignant melanoma with chondrosarcomatous differentiation in inguinal nodal metastasis
title_short BRAF‐mutated malignant melanoma with chondrosarcomatous differentiation in inguinal nodal metastasis
title_sort braf‐mutated malignant melanoma with chondrosarcomatous differentiation in inguinal nodal metastasis
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077358/
https://www.ncbi.nlm.nih.gov/pubmed/33936664
http://dx.doi.org/10.1002/ccr3.3982
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