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Combined Bacterial and Herpes Simplex Virus Keratitis following Small-Incision Lenticule Extraction for the Correction of Myopia

A 28-year-old male presented unilateral visual loss, intense ocular pain, redness and intraocular hypertension in his right eye 2 days after undergoing small-incision lenticule extraction (SMILE) in both eyes. Initial examination of the affected eye revealed the presence of white infiltrates within...

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Autores principales: Ramirez-Miranda, Arturo, Mangwani-Mordani, Simran, Quiroz-Casian, Natalia, Oliva-Bienzobas, Valeria, Cabral-Macias, Jesus, Navas, Alejandro, Graue-Hernandez, Enrique O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077540/
https://www.ncbi.nlm.nih.gov/pubmed/33976687
http://dx.doi.org/10.1159/000511374
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author Ramirez-Miranda, Arturo
Mangwani-Mordani, Simran
Quiroz-Casian, Natalia
Oliva-Bienzobas, Valeria
Cabral-Macias, Jesus
Navas, Alejandro
Graue-Hernandez, Enrique O.
author_facet Ramirez-Miranda, Arturo
Mangwani-Mordani, Simran
Quiroz-Casian, Natalia
Oliva-Bienzobas, Valeria
Cabral-Macias, Jesus
Navas, Alejandro
Graue-Hernandez, Enrique O.
author_sort Ramirez-Miranda, Arturo
collection PubMed
description A 28-year-old male presented unilateral visual loss, intense ocular pain, redness and intraocular hypertension in his right eye 2 days after undergoing small-incision lenticule extraction (SMILE) in both eyes. Initial examination of the affected eye revealed the presence of white infiltrates within the corneal interface, as well as a central epithelial defect. The patient was diagnosed with infectious keratitis, posteriorly the eye was irrigated with balanced saline solution and treatment was initiated with hourly moxifloxacin 0.5%. Since this approach failed to resolve symptoms, a sample from the interface was obtained for PCR assay, which revealed the presence of herpes simplex virus DNA, confirming the cause of the infection. The patient was prescribed a regimen of oral acyclovir, topical ganciclovir and prednisolone. Clinical improvement following resolution of the epithelial defect was observed. Although rare, herpetic keratitis following SMILE is best managed via early diagnosis and initiation of appropriate anti-herpetic treatment.
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spelling pubmed-80775402021-05-10 Combined Bacterial and Herpes Simplex Virus Keratitis following Small-Incision Lenticule Extraction for the Correction of Myopia Ramirez-Miranda, Arturo Mangwani-Mordani, Simran Quiroz-Casian, Natalia Oliva-Bienzobas, Valeria Cabral-Macias, Jesus Navas, Alejandro Graue-Hernandez, Enrique O. Case Rep Ophthalmol Case Report A 28-year-old male presented unilateral visual loss, intense ocular pain, redness and intraocular hypertension in his right eye 2 days after undergoing small-incision lenticule extraction (SMILE) in both eyes. Initial examination of the affected eye revealed the presence of white infiltrates within the corneal interface, as well as a central epithelial defect. The patient was diagnosed with infectious keratitis, posteriorly the eye was irrigated with balanced saline solution and treatment was initiated with hourly moxifloxacin 0.5%. Since this approach failed to resolve symptoms, a sample from the interface was obtained for PCR assay, which revealed the presence of herpes simplex virus DNA, confirming the cause of the infection. The patient was prescribed a regimen of oral acyclovir, topical ganciclovir and prednisolone. Clinical improvement following resolution of the epithelial defect was observed. Although rare, herpetic keratitis following SMILE is best managed via early diagnosis and initiation of appropriate anti-herpetic treatment. S. Karger AG 2021-04-12 /pmc/articles/PMC8077540/ /pubmed/33976687 http://dx.doi.org/10.1159/000511374 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Ramirez-Miranda, Arturo
Mangwani-Mordani, Simran
Quiroz-Casian, Natalia
Oliva-Bienzobas, Valeria
Cabral-Macias, Jesus
Navas, Alejandro
Graue-Hernandez, Enrique O.
Combined Bacterial and Herpes Simplex Virus Keratitis following Small-Incision Lenticule Extraction for the Correction of Myopia
title Combined Bacterial and Herpes Simplex Virus Keratitis following Small-Incision Lenticule Extraction for the Correction of Myopia
title_full Combined Bacterial and Herpes Simplex Virus Keratitis following Small-Incision Lenticule Extraction for the Correction of Myopia
title_fullStr Combined Bacterial and Herpes Simplex Virus Keratitis following Small-Incision Lenticule Extraction for the Correction of Myopia
title_full_unstemmed Combined Bacterial and Herpes Simplex Virus Keratitis following Small-Incision Lenticule Extraction for the Correction of Myopia
title_short Combined Bacterial and Herpes Simplex Virus Keratitis following Small-Incision Lenticule Extraction for the Correction of Myopia
title_sort combined bacterial and herpes simplex virus keratitis following small-incision lenticule extraction for the correction of myopia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077540/
https://www.ncbi.nlm.nih.gov/pubmed/33976687
http://dx.doi.org/10.1159/000511374
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