A Rare Case of Thyroid Carcinoma Showing Thymus-Like Differentiation in a Young Adult

Thyroid carcinoma showing thymus-like differentiation (CASTLE) is thought to originate from ectopic thymic tissue or remnants of the developing thymus within or adjacent to the thyroid. This case report describes a mass located on the left thyroid of a 28-year-old man. Fine-needle aspiration cytolog...

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Autores principales: Kimura, Eri, Enomoto, Keisuke, Kono, Masamitsu, Tamagawa, Shunji, Takeda, Saori, Kumashiro, Naoko, Hirayama, Shun, Kimura, Takahito, Hotomi, Muneki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077592/
https://www.ncbi.nlm.nih.gov/pubmed/33976651
http://dx.doi.org/10.1159/000514271
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author Kimura, Eri
Enomoto, Keisuke
Kono, Masamitsu
Tamagawa, Shunji
Takeda, Saori
Kumashiro, Naoko
Hirayama, Shun
Kimura, Takahito
Hotomi, Muneki
author_facet Kimura, Eri
Enomoto, Keisuke
Kono, Masamitsu
Tamagawa, Shunji
Takeda, Saori
Kumashiro, Naoko
Hirayama, Shun
Kimura, Takahito
Hotomi, Muneki
author_sort Kimura, Eri
collection PubMed
description Thyroid carcinoma showing thymus-like differentiation (CASTLE) is thought to originate from ectopic thymic tissue or remnants of the developing thymus within or adjacent to the thyroid. This case report describes a mass located on the left thyroid of a 28-year-old man. Fine-needle aspiration cytology revealed a number of lymphoid cells without atypia that were similar to those seen in a malignant lymphoma of the thyroid, and surgery was performed. Based on additional histopathological findings, the tumor was finally diagnosed as a CASTLE. It is difficult to diagnose this neoplasm using fine-needle aspiration cytology. However, it is possible to differentially diagnose CASTLE based on its histological features. CD5 is useful for diagnosing CASTLE with immunohistochemical staining.
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spelling pubmed-80775922021-05-10 A Rare Case of Thyroid Carcinoma Showing Thymus-Like Differentiation in a Young Adult Kimura, Eri Enomoto, Keisuke Kono, Masamitsu Tamagawa, Shunji Takeda, Saori Kumashiro, Naoko Hirayama, Shun Kimura, Takahito Hotomi, Muneki Case Rep Oncol Case Report Thyroid carcinoma showing thymus-like differentiation (CASTLE) is thought to originate from ectopic thymic tissue or remnants of the developing thymus within or adjacent to the thyroid. This case report describes a mass located on the left thyroid of a 28-year-old man. Fine-needle aspiration cytology revealed a number of lymphoid cells without atypia that were similar to those seen in a malignant lymphoma of the thyroid, and surgery was performed. Based on additional histopathological findings, the tumor was finally diagnosed as a CASTLE. It is difficult to diagnose this neoplasm using fine-needle aspiration cytology. However, it is possible to differentially diagnose CASTLE based on its histological features. CD5 is useful for diagnosing CASTLE with immunohistochemical staining. S. Karger AG 2021-04-12 /pmc/articles/PMC8077592/ /pubmed/33976651 http://dx.doi.org/10.1159/000514271 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Kimura, Eri
Enomoto, Keisuke
Kono, Masamitsu
Tamagawa, Shunji
Takeda, Saori
Kumashiro, Naoko
Hirayama, Shun
Kimura, Takahito
Hotomi, Muneki
A Rare Case of Thyroid Carcinoma Showing Thymus-Like Differentiation in a Young Adult
title A Rare Case of Thyroid Carcinoma Showing Thymus-Like Differentiation in a Young Adult
title_full A Rare Case of Thyroid Carcinoma Showing Thymus-Like Differentiation in a Young Adult
title_fullStr A Rare Case of Thyroid Carcinoma Showing Thymus-Like Differentiation in a Young Adult
title_full_unstemmed A Rare Case of Thyroid Carcinoma Showing Thymus-Like Differentiation in a Young Adult
title_short A Rare Case of Thyroid Carcinoma Showing Thymus-Like Differentiation in a Young Adult
title_sort rare case of thyroid carcinoma showing thymus-like differentiation in a young adult
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077592/
https://www.ncbi.nlm.nih.gov/pubmed/33976651
http://dx.doi.org/10.1159/000514271
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