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Manganese/bipyridine-catalyzed non-directed C(sp(3))–H bromination using NBS and TMSN(3)
A Mn(II)/bipyridine-catalyzed bromination reaction of unactivated aliphatic C(sp(3))−H bonds has been developed using N-bromosuccinimide (NBS) as the brominating reagent. The reaction proceeded in moderate-to-good yield, even on a gram scale. The introduced bromine atom can be converted into fluorin...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077618/ https://www.ncbi.nlm.nih.gov/pubmed/33968261 http://dx.doi.org/10.3762/bjoc.17.74 |
| Sumario: | A Mn(II)/bipyridine-catalyzed bromination reaction of unactivated aliphatic C(sp(3))−H bonds has been developed using N-bromosuccinimide (NBS) as the brominating reagent. The reaction proceeded in moderate-to-good yield, even on a gram scale. The introduced bromine atom can be converted into fluorine and allyl groups. |
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