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P2X(3) receptor upregulation in trigeminal ganglion neurons through TNFα production in macrophages contributes to trigeminal neuropathic pain in rats
BACKGROUND: Trigeminal neuralgia is a characteristic disease that manifests as orofacial phasic or continuous severe pain triggered by innocuous orofacial stimulation; its mechanisms are not fully understood. In this study, we established a new animal model of trigeminal neuralgia and investigated t...
Autores principales: | Koizumi, Momoko, Asano, Sayaka, Furukawa, Akihiko, Hayashi, Yoshinori, Hitomi, Suzuro, Shibuta, Ikuko, Hayashi, Katsuhiko, Kato, Fusao, Iwata, Koichi, Shinoda, Masamichi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Milan
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077728/ https://www.ncbi.nlm.nih.gov/pubmed/33902429 http://dx.doi.org/10.1186/s10194-021-01244-4 |
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