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Subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers
BACKGROUND: Bifenthrin is a pyrethroid. Chronic exposure of humans to the pesticide occurs. Reports about immunotoxicity and proinflammatory effect of pyrethroids were published. The aim of the article was to check if subacute poisoning with bifenthrin affects proinflammatory interleukin 1ß and tumo...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077818/ https://www.ncbi.nlm.nih.gov/pubmed/33902677 http://dx.doi.org/10.1186/s40360-021-00490-1 |
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author | Pylak-Piwko, Oktawia Nieradko-Iwanicka, Barbara |
author_facet | Pylak-Piwko, Oktawia Nieradko-Iwanicka, Barbara |
author_sort | Pylak-Piwko, Oktawia |
collection | PubMed |
description | BACKGROUND: Bifenthrin is a pyrethroid. Chronic exposure of humans to the pesticide occurs. Reports about immunotoxicity and proinflammatory effect of pyrethroids were published. The aim of the article was to check if subacute poisoning with bifenthrin affects proinflammatory interleukin 1ß and tumor necrosis factorα (TNFα) in kidneys, livers and the function of these organs. METHODS: Thirty two female mice were used. They were divided into 4 groups: controls, mice receiving 1.61 mg/kg bifenthrin for 28 days (group 1), 4.025 mg/kg (2), 8.05 mg/kg (3). On day 29 they were sacrificed, blood, livers and kidneys were obtained. Creatinine concentration and alanine transaminase (ALT) activity were estimated in the blood sera. Interleukin1ß and TNFα concentrations in the organs were measured. RESULT: Mean interleukin 1ß concentration in the livers of controls was 53 pg/ml, in group 1- 54 pg/ml, 2- 59 pg/ml, 3- 99 pg/ml (p < 0.05 vs controls). It was accompanied by significant increase in ALT activity in group 3 vs controls (p < 0.05). In the control kidneys interleukin 1ß was 3.9 pg/ml, group 1–6.8 pg/ml, 2–9.8 pg/ml and 3- 11 pg/ml. Statistically significant difference between group 1, 2 and 3 vs controls was found. There was no significant differences among the groups in TNFα concentrations neither in the livers nor kidneys. CONCLUSION: Subacute poisoning with bifenthrin significantly increases interleukin 1ß concentration in livers and kidneys in a dose-proportionate level. It is accompanied by ALT activity increase. It confirms nephrotoxic and hepatotoxic and pro-inflammatory effect of bifenthrin in non-target organisms. |
format | Online Article Text |
id | pubmed-8077818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-80778182021-04-29 Subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers Pylak-Piwko, Oktawia Nieradko-Iwanicka, Barbara BMC Pharmacol Toxicol Research Article BACKGROUND: Bifenthrin is a pyrethroid. Chronic exposure of humans to the pesticide occurs. Reports about immunotoxicity and proinflammatory effect of pyrethroids were published. The aim of the article was to check if subacute poisoning with bifenthrin affects proinflammatory interleukin 1ß and tumor necrosis factorα (TNFα) in kidneys, livers and the function of these organs. METHODS: Thirty two female mice were used. They were divided into 4 groups: controls, mice receiving 1.61 mg/kg bifenthrin for 28 days (group 1), 4.025 mg/kg (2), 8.05 mg/kg (3). On day 29 they were sacrificed, blood, livers and kidneys were obtained. Creatinine concentration and alanine transaminase (ALT) activity were estimated in the blood sera. Interleukin1ß and TNFα concentrations in the organs were measured. RESULT: Mean interleukin 1ß concentration in the livers of controls was 53 pg/ml, in group 1- 54 pg/ml, 2- 59 pg/ml, 3- 99 pg/ml (p < 0.05 vs controls). It was accompanied by significant increase in ALT activity in group 3 vs controls (p < 0.05). In the control kidneys interleukin 1ß was 3.9 pg/ml, group 1–6.8 pg/ml, 2–9.8 pg/ml and 3- 11 pg/ml. Statistically significant difference between group 1, 2 and 3 vs controls was found. There was no significant differences among the groups in TNFα concentrations neither in the livers nor kidneys. CONCLUSION: Subacute poisoning with bifenthrin significantly increases interleukin 1ß concentration in livers and kidneys in a dose-proportionate level. It is accompanied by ALT activity increase. It confirms nephrotoxic and hepatotoxic and pro-inflammatory effect of bifenthrin in non-target organisms. BioMed Central 2021-04-26 /pmc/articles/PMC8077818/ /pubmed/33902677 http://dx.doi.org/10.1186/s40360-021-00490-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Pylak-Piwko, Oktawia Nieradko-Iwanicka, Barbara Subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers |
title | Subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers |
title_full | Subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers |
title_fullStr | Subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers |
title_full_unstemmed | Subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers |
title_short | Subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers |
title_sort | subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077818/ https://www.ncbi.nlm.nih.gov/pubmed/33902677 http://dx.doi.org/10.1186/s40360-021-00490-1 |
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