Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report

BACKGROUND: In patients with hepatitis C virus (HCV) and malignant lymphoma, hepatitis C flare during R-CHOP can result in discontinuation of treatment. However, appropriate therapeutic strategies for managing hepatitis C flare during R-CHOP have not been established, and this issue is complicated b...

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Autores principales: Umemura, Machiko, Suda, Goki, Tsukamoto, Shihori, Ebata, Ko, Takahash, Shinjiro, Sasaki, Takashi, Nakajima, Sae, Hirata, Koji, Ozasa, Mariko, Takano, Masatoshi, Katagiri, Masaki, Sakamoto, Naoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077834/
https://www.ncbi.nlm.nih.gov/pubmed/33906643
http://dx.doi.org/10.1186/s12879-021-06091-x
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author Umemura, Machiko
Suda, Goki
Tsukamoto, Shihori
Ebata, Ko
Takahash, Shinjiro
Sasaki, Takashi
Nakajima, Sae
Hirata, Koji
Ozasa, Mariko
Takano, Masatoshi
Katagiri, Masaki
Sakamoto, Naoya
author_facet Umemura, Machiko
Suda, Goki
Tsukamoto, Shihori
Ebata, Ko
Takahash, Shinjiro
Sasaki, Takashi
Nakajima, Sae
Hirata, Koji
Ozasa, Mariko
Takano, Masatoshi
Katagiri, Masaki
Sakamoto, Naoya
author_sort Umemura, Machiko
collection PubMed
description BACKGROUND: In patients with hepatitis C virus (HCV) and malignant lymphoma, hepatitis C flare during R-CHOP can result in discontinuation of treatment. However, appropriate therapeutic strategies for managing hepatitis C flare during R-CHOP have not been established, and this issue is complicated by conflicting results regarding the use of direct-acting antivirals in patients with uncontrolled malignancies. CASE PRESENTATION: We report the first case of effective and safe treatment with on-demand 8-week glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in a patient with diffuse large B-cell lymphoma (DLBCL). The patient completed five additional courses of R-CHOP without hepatic toxicity. A complete response of DLBCL and a sustained virological response were observed at 24 weeks after glecaprevir and pibrentasvir completion. CONCLUSION: On-demand, direct-acting antivirals could be a novel strategy for managing hepatitis C flare during R-CHOP. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-06091-x.
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spelling pubmed-80778342021-04-29 Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report Umemura, Machiko Suda, Goki Tsukamoto, Shihori Ebata, Ko Takahash, Shinjiro Sasaki, Takashi Nakajima, Sae Hirata, Koji Ozasa, Mariko Takano, Masatoshi Katagiri, Masaki Sakamoto, Naoya BMC Infect Dis Case Report BACKGROUND: In patients with hepatitis C virus (HCV) and malignant lymphoma, hepatitis C flare during R-CHOP can result in discontinuation of treatment. However, appropriate therapeutic strategies for managing hepatitis C flare during R-CHOP have not been established, and this issue is complicated by conflicting results regarding the use of direct-acting antivirals in patients with uncontrolled malignancies. CASE PRESENTATION: We report the first case of effective and safe treatment with on-demand 8-week glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in a patient with diffuse large B-cell lymphoma (DLBCL). The patient completed five additional courses of R-CHOP without hepatic toxicity. A complete response of DLBCL and a sustained virological response were observed at 24 weeks after glecaprevir and pibrentasvir completion. CONCLUSION: On-demand, direct-acting antivirals could be a novel strategy for managing hepatitis C flare during R-CHOP. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-06091-x. BioMed Central 2021-04-27 /pmc/articles/PMC8077834/ /pubmed/33906643 http://dx.doi.org/10.1186/s12879-021-06091-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Umemura, Machiko
Suda, Goki
Tsukamoto, Shihori
Ebata, Ko
Takahash, Shinjiro
Sasaki, Takashi
Nakajima, Sae
Hirata, Koji
Ozasa, Mariko
Takano, Masatoshi
Katagiri, Masaki
Sakamoto, Naoya
Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report
title Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report
title_full Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report
title_fullStr Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report
title_full_unstemmed Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report
title_short Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report
title_sort successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis c flare during r-chop in patients with diffuse large b-cell lymphoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077834/
https://www.ncbi.nlm.nih.gov/pubmed/33906643
http://dx.doi.org/10.1186/s12879-021-06091-x
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