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Matrix Stiffness Modulates Mechanical Interactions and Promotes Contact between Motile Cells
The mechanical micro-environment of cells and tissues influences key aspects of cell structure and function, including cell motility. For proper tissue development, cells need to migrate, interact, and form contacts. Cells are known to exert contractile forces on underlying soft substrates and sense...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077938/ https://www.ncbi.nlm.nih.gov/pubmed/33920918 http://dx.doi.org/10.3390/biomedicines9040428 |
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author | Bose, Subhaya Dasbiswas, Kinjal Gopinath, Arvind |
author_facet | Bose, Subhaya Dasbiswas, Kinjal Gopinath, Arvind |
author_sort | Bose, Subhaya |
collection | PubMed |
description | The mechanical micro-environment of cells and tissues influences key aspects of cell structure and function, including cell motility. For proper tissue development, cells need to migrate, interact, and form contacts. Cells are known to exert contractile forces on underlying soft substrates and sense deformations in them. Here, we propose and analyze a minimal biophysical model for cell migration and long-range cell–cell interactions through mutual mechanical deformations of the substrate. We compute key metrics of cell motile behavior, such as the number of cell-cell contacts over a given time, the dispersion of cell trajectories, and the probability of permanent cell contact, and analyze how these depend on a cell motility parameter and substrate stiffness. Our results elucidate how cells may sense each other mechanically and generate coordinated movements and provide an extensible framework to further address both mechanical and short-range biophysical interactions. |
format | Online Article Text |
id | pubmed-8077938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80779382021-04-28 Matrix Stiffness Modulates Mechanical Interactions and Promotes Contact between Motile Cells Bose, Subhaya Dasbiswas, Kinjal Gopinath, Arvind Biomedicines Article The mechanical micro-environment of cells and tissues influences key aspects of cell structure and function, including cell motility. For proper tissue development, cells need to migrate, interact, and form contacts. Cells are known to exert contractile forces on underlying soft substrates and sense deformations in them. Here, we propose and analyze a minimal biophysical model for cell migration and long-range cell–cell interactions through mutual mechanical deformations of the substrate. We compute key metrics of cell motile behavior, such as the number of cell-cell contacts over a given time, the dispersion of cell trajectories, and the probability of permanent cell contact, and analyze how these depend on a cell motility parameter and substrate stiffness. Our results elucidate how cells may sense each other mechanically and generate coordinated movements and provide an extensible framework to further address both mechanical and short-range biophysical interactions. MDPI 2021-04-15 /pmc/articles/PMC8077938/ /pubmed/33920918 http://dx.doi.org/10.3390/biomedicines9040428 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bose, Subhaya Dasbiswas, Kinjal Gopinath, Arvind Matrix Stiffness Modulates Mechanical Interactions and Promotes Contact between Motile Cells |
title | Matrix Stiffness Modulates Mechanical Interactions and Promotes Contact between Motile Cells |
title_full | Matrix Stiffness Modulates Mechanical Interactions and Promotes Contact between Motile Cells |
title_fullStr | Matrix Stiffness Modulates Mechanical Interactions and Promotes Contact between Motile Cells |
title_full_unstemmed | Matrix Stiffness Modulates Mechanical Interactions and Promotes Contact between Motile Cells |
title_short | Matrix Stiffness Modulates Mechanical Interactions and Promotes Contact between Motile Cells |
title_sort | matrix stiffness modulates mechanical interactions and promotes contact between motile cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077938/ https://www.ncbi.nlm.nih.gov/pubmed/33920918 http://dx.doi.org/10.3390/biomedicines9040428 |
work_keys_str_mv | AT bosesubhaya matrixstiffnessmodulatesmechanicalinteractionsandpromotescontactbetweenmotilecells AT dasbiswaskinjal matrixstiffnessmodulatesmechanicalinteractionsandpromotescontactbetweenmotilecells AT gopinatharvind matrixstiffnessmodulatesmechanicalinteractionsandpromotescontactbetweenmotilecells |