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Reduced Retinal Microvascular Perfusion in Patients With Stroke Detected by Optical Coherence Tomography Angiography

Currently there is a shortage of biomarkers for stroke, one of the leading causes of death and disability in aging populations. Retinal vessels offer a unique and accessible “window” to study the microvasculature in vivo. However, the relationship between the retinal microvasculature and stroke is n...

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Autores principales: Liu, Baoyi, Hu, Yijun, Ma, Guixian, Xiao, Yu, Zhang, Bin, Liang, Yingying, Zhong, Pingting, Zeng, Xiaomin, Lin, Zhanjie, Kong, Huiqian, Wu, Guanrong, Du, Zijing, Fang, Ying, Huang, Manqing, Wang, Lijuan, Yang, Xiaohong, Yu, Honghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078175/
https://www.ncbi.nlm.nih.gov/pubmed/33927607
http://dx.doi.org/10.3389/fnagi.2021.628336
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author Liu, Baoyi
Hu, Yijun
Ma, Guixian
Xiao, Yu
Zhang, Bin
Liang, Yingying
Zhong, Pingting
Zeng, Xiaomin
Lin, Zhanjie
Kong, Huiqian
Wu, Guanrong
Du, Zijing
Fang, Ying
Huang, Manqing
Wang, Lijuan
Yang, Xiaohong
Yu, Honghua
author_facet Liu, Baoyi
Hu, Yijun
Ma, Guixian
Xiao, Yu
Zhang, Bin
Liang, Yingying
Zhong, Pingting
Zeng, Xiaomin
Lin, Zhanjie
Kong, Huiqian
Wu, Guanrong
Du, Zijing
Fang, Ying
Huang, Manqing
Wang, Lijuan
Yang, Xiaohong
Yu, Honghua
author_sort Liu, Baoyi
collection PubMed
description Currently there is a shortage of biomarkers for stroke, one of the leading causes of death and disability in aging populations. Retinal vessels offer a unique and accessible “window” to study the microvasculature in vivo. However, the relationship between the retinal microvasculature and stroke is not entirely clear. To investigate the retinal microvascular characteristics in stroke, we recruited patients with stroke and age-matched control subjects from a tertiary hospital in China. The macular vessel density (VD) in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), foveal avascular zone (FAZ) metrics, and optical coherence tomography angiography (OCTA) measured optic disc VD were recorded for analysis. A total of 189 patients with stroke and 195 control subjects were included. After adjusting for sex, visual acuity, systolic and diastolic blood pressure, a history of smoking, levels of hemoglobulin (HbA1c), cholesterol, and high-density lipoprotein (HDL), the macular VD of SCP and DCP in all sectors was decreased in patients with stroke. In the stroke group, the VD around the FAZ and the VD of the optic disk were lower. Logistic regression found the parafovea-superior-hemi VD of DCP > 54.53% [odds ratio (OR): 0.169] as a protective factor of stroke. Using the integration of all OCTA parameters and traditional risk factors, the area under the receiver operating characteristic (AUC) curve of distinguishing patients with stroke was 0.962, with a sensitivity of 0.944 and a specificity of 0.871. Our study demonstrates that the retinal VD is decreased in patients with stroke independently of the traditional risk factors of stroke, which may shed light on the monitoring of stroke using the retinal microvascular parameters.
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spelling pubmed-80781752021-04-28 Reduced Retinal Microvascular Perfusion in Patients With Stroke Detected by Optical Coherence Tomography Angiography Liu, Baoyi Hu, Yijun Ma, Guixian Xiao, Yu Zhang, Bin Liang, Yingying Zhong, Pingting Zeng, Xiaomin Lin, Zhanjie Kong, Huiqian Wu, Guanrong Du, Zijing Fang, Ying Huang, Manqing Wang, Lijuan Yang, Xiaohong Yu, Honghua Front Aging Neurosci Neuroscience Currently there is a shortage of biomarkers for stroke, one of the leading causes of death and disability in aging populations. Retinal vessels offer a unique and accessible “window” to study the microvasculature in vivo. However, the relationship between the retinal microvasculature and stroke is not entirely clear. To investigate the retinal microvascular characteristics in stroke, we recruited patients with stroke and age-matched control subjects from a tertiary hospital in China. The macular vessel density (VD) in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), foveal avascular zone (FAZ) metrics, and optical coherence tomography angiography (OCTA) measured optic disc VD were recorded for analysis. A total of 189 patients with stroke and 195 control subjects were included. After adjusting for sex, visual acuity, systolic and diastolic blood pressure, a history of smoking, levels of hemoglobulin (HbA1c), cholesterol, and high-density lipoprotein (HDL), the macular VD of SCP and DCP in all sectors was decreased in patients with stroke. In the stroke group, the VD around the FAZ and the VD of the optic disk were lower. Logistic regression found the parafovea-superior-hemi VD of DCP > 54.53% [odds ratio (OR): 0.169] as a protective factor of stroke. Using the integration of all OCTA parameters and traditional risk factors, the area under the receiver operating characteristic (AUC) curve of distinguishing patients with stroke was 0.962, with a sensitivity of 0.944 and a specificity of 0.871. Our study demonstrates that the retinal VD is decreased in patients with stroke independently of the traditional risk factors of stroke, which may shed light on the monitoring of stroke using the retinal microvascular parameters. Frontiers Media S.A. 2021-04-13 /pmc/articles/PMC8078175/ /pubmed/33927607 http://dx.doi.org/10.3389/fnagi.2021.628336 Text en Copyright © 2021 Liu, Hu, Ma, Xiao, Zhang, Liang, Zhong, Zeng, Lin, Kong, Wu, Du, Fang, Huang, Wang, Yang and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Baoyi
Hu, Yijun
Ma, Guixian
Xiao, Yu
Zhang, Bin
Liang, Yingying
Zhong, Pingting
Zeng, Xiaomin
Lin, Zhanjie
Kong, Huiqian
Wu, Guanrong
Du, Zijing
Fang, Ying
Huang, Manqing
Wang, Lijuan
Yang, Xiaohong
Yu, Honghua
Reduced Retinal Microvascular Perfusion in Patients With Stroke Detected by Optical Coherence Tomography Angiography
title Reduced Retinal Microvascular Perfusion in Patients With Stroke Detected by Optical Coherence Tomography Angiography
title_full Reduced Retinal Microvascular Perfusion in Patients With Stroke Detected by Optical Coherence Tomography Angiography
title_fullStr Reduced Retinal Microvascular Perfusion in Patients With Stroke Detected by Optical Coherence Tomography Angiography
title_full_unstemmed Reduced Retinal Microvascular Perfusion in Patients With Stroke Detected by Optical Coherence Tomography Angiography
title_short Reduced Retinal Microvascular Perfusion in Patients With Stroke Detected by Optical Coherence Tomography Angiography
title_sort reduced retinal microvascular perfusion in patients with stroke detected by optical coherence tomography angiography
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078175/
https://www.ncbi.nlm.nih.gov/pubmed/33927607
http://dx.doi.org/10.3389/fnagi.2021.628336
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