Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis

Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH(2)O (adjusted odds ratio [aOR], 2.56; 95%...

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Detalles Bibliográficos
Autores principales: Molloy, Síle F, Ross, Brad, Kanyama, Cecilia, Mfinanga, Sayoki, Lesikari, Sokoine, Heyderman, Robert S, Kalata, Newton, Ellis, Jayne, Kouanfack, Charles, Chanda, Duncan, Temfack, Elvis, Lakhi, Shabir, Moodley, Anand, Chan, Adrienne K, van Oosterhout, Joep J, Mapoure, Yacouba, Mwaba, Peter, Lalloo, David G, Wang, Duolao, Lortholary, Olivier, Jaffar, Shabbar, Hosseinipour, Mina C, Loyse, Angela, Harrison, Thomas S, Bicanic, Tihana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078267/
https://www.ncbi.nlm.nih.gov/pubmed/33937434
http://dx.doi.org/10.1093/ofid/ofab066
Descripción
Sumario:Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH(2)O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36–4.83; P = .02) and fungal burden >6.0 log(10) colonies/mL (aOR, 3.01; 95% CI, 1.58–5.7; P = .003) were independently associated with severe visual loss.

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