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Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis
Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH(2)O (adjusted odds ratio [aOR], 2.56; 95%...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078267/ https://www.ncbi.nlm.nih.gov/pubmed/33937434 http://dx.doi.org/10.1093/ofid/ofab066 |
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| author | Molloy, Síle F Ross, Brad Kanyama, Cecilia Mfinanga, Sayoki Lesikari, Sokoine Heyderman, Robert S Kalata, Newton Ellis, Jayne Kouanfack, Charles Chanda, Duncan Temfack, Elvis Lakhi, Shabir Moodley, Anand Chan, Adrienne K van Oosterhout, Joep J Mapoure, Yacouba Mwaba, Peter Lalloo, David G Wang, Duolao Lortholary, Olivier Jaffar, Shabbar Hosseinipour, Mina C Loyse, Angela Harrison, Thomas S Bicanic, Tihana |
| author_facet | Molloy, Síle F Ross, Brad Kanyama, Cecilia Mfinanga, Sayoki Lesikari, Sokoine Heyderman, Robert S Kalata, Newton Ellis, Jayne Kouanfack, Charles Chanda, Duncan Temfack, Elvis Lakhi, Shabir Moodley, Anand Chan, Adrienne K van Oosterhout, Joep J Mapoure, Yacouba Mwaba, Peter Lalloo, David G Wang, Duolao Lortholary, Olivier Jaffar, Shabbar Hosseinipour, Mina C Loyse, Angela Harrison, Thomas S Bicanic, Tihana |
| author_sort | Molloy, Síle F |
| collection | PubMed |
| description | Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH(2)O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36–4.83; P = .02) and fungal burden >6.0 log(10) colonies/mL (aOR, 3.01; 95% CI, 1.58–5.7; P = .003) were independently associated with severe visual loss. |
| format | Online Article Text |
| id | pubmed-8078267 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-80782672021-04-30 Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis Molloy, Síle F Ross, Brad Kanyama, Cecilia Mfinanga, Sayoki Lesikari, Sokoine Heyderman, Robert S Kalata, Newton Ellis, Jayne Kouanfack, Charles Chanda, Duncan Temfack, Elvis Lakhi, Shabir Moodley, Anand Chan, Adrienne K van Oosterhout, Joep J Mapoure, Yacouba Mwaba, Peter Lalloo, David G Wang, Duolao Lortholary, Olivier Jaffar, Shabbar Hosseinipour, Mina C Loyse, Angela Harrison, Thomas S Bicanic, Tihana Open Forum Infect Dis Brief Reports Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH(2)O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36–4.83; P = .02) and fungal burden >6.0 log(10) colonies/mL (aOR, 3.01; 95% CI, 1.58–5.7; P = .003) were independently associated with severe visual loss. Oxford University Press 2021-02-05 /pmc/articles/PMC8078267/ /pubmed/33937434 http://dx.doi.org/10.1093/ofid/ofab066 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Brief Reports Molloy, Síle F Ross, Brad Kanyama, Cecilia Mfinanga, Sayoki Lesikari, Sokoine Heyderman, Robert S Kalata, Newton Ellis, Jayne Kouanfack, Charles Chanda, Duncan Temfack, Elvis Lakhi, Shabir Moodley, Anand Chan, Adrienne K van Oosterhout, Joep J Mapoure, Yacouba Mwaba, Peter Lalloo, David G Wang, Duolao Lortholary, Olivier Jaffar, Shabbar Hosseinipour, Mina C Loyse, Angela Harrison, Thomas S Bicanic, Tihana Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis |
| title | Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis |
| title_full | Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis |
| title_fullStr | Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis |
| title_full_unstemmed | Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis |
| title_short | Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis |
| title_sort | fungal burden and raised intracranial pressure are independently associated with visual loss in human immunodeficiency virus-associated cryptococcal meningitis |
| topic | Brief Reports |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078267/ https://www.ncbi.nlm.nih.gov/pubmed/33937434 http://dx.doi.org/10.1093/ofid/ofab066 |
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