Cargando…

NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform Neurofibromas

Patients with neurofibromatosis type 1 (NF1) frequently develop plexiform neurofibromas (PNs), which can cause significant morbidity. We performed a phase II trial of the MAPK/ERK kinase inhibitor, mirdametinib (PD-0325901), in patients with NF1 and inoperable PNs. The primary objective was response...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weiss, Brian D., Wolters, Pamela L., Plotkin, Scott R., Widemann, Brigitte C., Tonsgard, James H., Blakeley, Jaishri, Allen, Jeffrey C., Schorry, Elizabeth, Korf, Bruce, Robison, Nathan J., Goldman, Stewart, Vinks, Alexander A., Emoto, Chie, Fukuda, Tsuyoshi, Robinson, Coretta T., Cutter, Gary, Edwards, Lloyd, Dombi, Eva, Ratner, Nancy, Packer, Roger, Fisher, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Clinical Oncology 2021
Materias:	Original Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078274/ https://www.ncbi.nlm.nih.gov/pubmed/33507822 http://dx.doi.org/10.1200/JCO.20.02220

Ejemplares similares

NFB-17. MEK INHIBITOR BINIMETINIB SHOWS CLINICAL ACTIVITY IN CHILDREN WITH NEUROFIBROMATOSIS TYPE 1- ASSOCIATED PLEXIFORM NEUROFIBROMAS: A REPORT FROM PNOC AND THE NF CLINICAL TRIALS CONSORTIUM
por: Mueller, Sabine, et al.
Publicado: (2020)

Clinical trial design for cutaneous neurofibromas
por: Cannon, Ashley, et al.
Publicado: (2018)

Giant scalp plexiform neurofibroma associated with NF-1
por: Munakomi, Sunil
Publicado: (2017)

Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment
por: Kershner, Leah J., et al.
Publicado: (2022)

A molecular basis for neurofibroma-associated skeletal manifestations in NF1
por: Ma, Yun, et al.
Publicado: (2020)

A qualitative study of the impact of plexiform neurofibromas on need fulfilment in adults with neurofibromatosis type 1
por: Heaney, Alice, et al.
Publicado: (2019)

Multicenter, prospective, phase II study of maintenance bevacizumab for children and adults with NF2-related schwannomatosis and progressive vestibular schwannoma
por: Plotkin, Scott R, et al.
Publicado: (2023)

Growth dynamics of plexiform neurofibromas: a retrospective cohort study of 201 patients with neurofibromatosis 1
por: Nguyen, Rosa, et al.
Publicado: (2012)

NFB-03. TRAMETINIB FOR ORBITAL PLEXIFORM NEUROFIBROMAS IN YOUNG CHILDREN WITH NF1
por: Toledano, Helen, et al.
Publicado: (2020)

MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK
por: Na, Youjin, et al.
Publicado: (2020)

Non-coding RNA ANRIL and the number of plexiform neurofibromas in patients with NF1 microdeletions
por: Mußotter, Tanja, et al.
Publicado: (2012)

Oral plexiform neurofibroma
por: Wu, Yu-Hsueh, et al.
Publicado: (2016)

The development of the PlexiQoL: A patient‐reported outcome measure for adults with neurofibromatosis type 1‐associated plexiform neurofibromas
por: Heaney, Alice, et al.
Publicado: (2020)

Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived schwann cells
por: Ferrer, Marc, et al.
Publicado: (2018)

Creating a comprehensive research strategy for cutaneous neurofibromas
por: Blakeley, Jaishri O., et al.
Publicado: (2018)

Isolated Plexiform Neurofibroma of the Tongue
por: Sharma, Abhishek, et al.
Publicado: (2013)

Plexiform Neurofibroma Treated with Pharmacopuncture
por: Lim, Chungsan, et al.
Publicado: (2014)

Irradiation of Nf1 mutant mouse models of spinal plexiform neurofibromas drives pathologic progression and decreases survival
por: Laurent, Danny, et al.
Publicado: (2021)

Pelvic plexiform neurofibroma during bowel/bladder dysfunction in an NF1 pediatric patient: A case report
por: Allen, Ricci, et al.
Publicado: (2021)

NFB-12. Effect of trametinib on leg length discrepancy in a child with NF1 related plexiform neurofibroma
por: Pradeep, Celia, et al.
Publicado: (2022)

Plexiform Neurofibroma in the Axilla with Intraosseous Neurofibroma in the Humerus in Neurofibromatosis 5
por: Khaladkar, Sanjay Mhalasakant, et al.
Publicado: (2018)

Plexiform Neurofibroma: A Case Report
por: Tchernev, Georgi, et al.
Publicado: (2016)

Massive Plexiform Neurofibroma of the Neck and Larynx
por: Mobashir, Mohammad Kamal, et al.
Publicado: (2014)

Plexiform Neurofibroma Involving the Lacrimal Gland
por: Hofsli, Mikael, et al.
Publicado: (2017)

Increased nuclear translation of YAP might act as a potential therapeutic target for NF1-related plexiform neurofibroma
por: Liu, Jia-Liang, et al.
Publicado: (2021)

Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling
por: Grit, Jamie L., et al.
Publicado: (2021)

After Nf1 loss in Schwann cells, inflammation drives neurofibroma formation
por: Fletcher, Jonathan S, et al.
Publicado: (2019)

Genitourinary Plexiform Neurofibroma Mimicking Sacrococcygeal Teratoma
por: Nasir, Abdulrasheed A., et al.
Publicado: (2012)

BCRP expression in schwannoma, plexiform neurofibroma and MPNST
por: de Vries, Maurits, et al.
Publicado: (2017)

Plexiform neurofibroma with nevus of ota-rare presentation
por: Taneja, Lavina, et al.
Publicado: (2021)

Epidemiological and clinical burden associated with plexiform neurofibromas in pediatric neurofibromatosis type-1 (NF-1): a systematic literature review
por: Iheanacho, Ike, et al.
Publicado: (2021)

Perinatal folate levels do not influence tumor latency or multiplicity in a model of NF1 associated plexiform-like neurofibromas
por: Williams, Kyle B., et al.
Publicado: (2023)

Integration of single-nuclei RNA-sequencing, spatial transcriptomics and histochemistry defines the complex microenvironment of NF1-associated plexiform neurofibromas
por: Amani, Vladimir, et al.
Publicado: (2023)

Superimposed Mosaicism in the Form of Extremely Extended Segmental Plexiform Neurofibroma Caused by a Novel Pathogenic Variant in the NF1 Gene
por: Veres, Klára, et al.
Publicado: (2023)

Whole Body MRI at 3T with Quantitative Diffusion Weighted Imaging and Contrast-Enhanced Sequences for the Characterization of Peripheral Lesions in Patients with Neurofibromatosis Type 2 and Schwannomatosis
por: Fayad, Laura M., et al.
Publicado: (2013)

Giant Pelvic Neurofibroma in Patient with Plexiform Sciatic Neurofibroma and Neurofibromatosis Type 1
por: Temelkova, Ivanka, et al.
Publicado: (2019)

RARE-06. CLINICAL BURDEN AMONG PATIENTS WITH NEUROFIBROMATOSIS TYPE 1 (NF1) AND PLEXIFORM NEUROFIBROMA (PN) IN THE UNITED STATES (US)
por: Yang, Xiaoqin, et al.
Publicado: (2021)

LGG-22. SJ901: Phase I/II evaluation of single agent mirdametinib (PD-0325901), a brain-penetrant MEK1/2 inhibitor, for the treatment of children, adolescents, and young adults with low-grade glioma (LGG)
por: Vinitsky, Anna, et al.
Publicado: (2022)

Giant plexiform neurofibroma presenting with craniovertebral junction instability
por: Menon, Bindu, et al.
Publicado: (2010)

Isolated plexiform neurofibroma mimicking a vascular lesion
por: Stefano, Paola Cecilia, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_m2i9rc0dcg0fbchetctgfmm3ge