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The clinical prognostic value of lncRNA LINC00675 in cancer patients: A meta-analysis

A newly discovered long non-coding RNA (lncRNA) is associated with the progression of a variety of tumors. The purpose of this meta-analysis is to explore further the relationship between clinicopathological features and the prognostic value of LINC00675 in caners. We searched the various database,...

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Autores principales: Hua, Hao, Wang, Jie, Zhong, Pingyong, Mou, Tinggang, Liu, Pan, Xie, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078383/
https://www.ncbi.nlm.nih.gov/pubmed/33879657
http://dx.doi.org/10.1097/MD.0000000000025244
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author Hua, Hao
Wang, Jie
Zhong, Pingyong
Mou, Tinggang
Liu, Pan
Xie, Fei
author_facet Hua, Hao
Wang, Jie
Zhong, Pingyong
Mou, Tinggang
Liu, Pan
Xie, Fei
author_sort Hua, Hao
collection PubMed
description A newly discovered long non-coding RNA (lncRNA) is associated with the progression of a variety of tumors. The purpose of this meta-analysis is to explore further the relationship between clinicopathological features and the prognostic value of LINC00675 in caners. We searched the various database, including PubMed, Web of Science, Cochrane Library, Embase together with Wanfang, and China National Knowledge Infrastructure for articles on LINC00675 and clinicopathological characteristics and prognosis of patients with cancers before February 20, 2020. According to the inclusion and exclusion criteria, the studies that meet the criteria were systematically collected through search keywords. The Newcastle Ottawa document quality assessment system was used to evaluate the quality of documents. The required data from literature were extracted, and the hazard ratio (HR), odds ratio (OR), and 95confidence interval (CI) were calculated using stata12.0 software and RevMan5.3 software. A total of 5 studies covering 462 patients were included in this meta-analysis to evaluate the prognostic value of LINC00675 in cancers. Our results showed that high LINC00675 expression was significantly correlated with poor overall survival (OS) (HR = 1.60, 95% CI: 1.23–2.08, P = .0005). Additionally, upregulated expression of LINC00675 was significantly associated with tumor node metastasis stage (OR = 1.74, 95% CI: 1.18–2.58, P = .006) and distant metastasis (OR = 2.22, 95% CI: 1.21–4.08, P = .01). Our study suggests that LINC00675 could be used as a biomarker to evaluate the prognosis of cancer patients. More studies to further confirm that the clinical value of LINC00675 in cancers will be required.
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spelling pubmed-80783832021-04-27 The clinical prognostic value of lncRNA LINC00675 in cancer patients: A meta-analysis Hua, Hao Wang, Jie Zhong, Pingyong Mou, Tinggang Liu, Pan Xie, Fei Medicine (Baltimore) 5700 A newly discovered long non-coding RNA (lncRNA) is associated with the progression of a variety of tumors. The purpose of this meta-analysis is to explore further the relationship between clinicopathological features and the prognostic value of LINC00675 in caners. We searched the various database, including PubMed, Web of Science, Cochrane Library, Embase together with Wanfang, and China National Knowledge Infrastructure for articles on LINC00675 and clinicopathological characteristics and prognosis of patients with cancers before February 20, 2020. According to the inclusion and exclusion criteria, the studies that meet the criteria were systematically collected through search keywords. The Newcastle Ottawa document quality assessment system was used to evaluate the quality of documents. The required data from literature were extracted, and the hazard ratio (HR), odds ratio (OR), and 95confidence interval (CI) were calculated using stata12.0 software and RevMan5.3 software. A total of 5 studies covering 462 patients were included in this meta-analysis to evaluate the prognostic value of LINC00675 in cancers. Our results showed that high LINC00675 expression was significantly correlated with poor overall survival (OS) (HR = 1.60, 95% CI: 1.23–2.08, P = .0005). Additionally, upregulated expression of LINC00675 was significantly associated with tumor node metastasis stage (OR = 1.74, 95% CI: 1.18–2.58, P = .006) and distant metastasis (OR = 2.22, 95% CI: 1.21–4.08, P = .01). Our study suggests that LINC00675 could be used as a biomarker to evaluate the prognosis of cancer patients. More studies to further confirm that the clinical value of LINC00675 in cancers will be required. Lippincott Williams & Wilkins 2021-04-23 /pmc/articles/PMC8078383/ /pubmed/33879657 http://dx.doi.org/10.1097/MD.0000000000025244 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 5700
Hua, Hao
Wang, Jie
Zhong, Pingyong
Mou, Tinggang
Liu, Pan
Xie, Fei
The clinical prognostic value of lncRNA LINC00675 in cancer patients: A meta-analysis
title The clinical prognostic value of lncRNA LINC00675 in cancer patients: A meta-analysis
title_full The clinical prognostic value of lncRNA LINC00675 in cancer patients: A meta-analysis
title_fullStr The clinical prognostic value of lncRNA LINC00675 in cancer patients: A meta-analysis
title_full_unstemmed The clinical prognostic value of lncRNA LINC00675 in cancer patients: A meta-analysis
title_short The clinical prognostic value of lncRNA LINC00675 in cancer patients: A meta-analysis
title_sort clinical prognostic value of lncrna linc00675 in cancer patients: a meta-analysis
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078383/
https://www.ncbi.nlm.nih.gov/pubmed/33879657
http://dx.doi.org/10.1097/MD.0000000000025244
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