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Afterdischarges in Myasthenia Gravis
Introduction: This study aimed to analyze the clinical features of myasthenia gravis (MG) in combination with the afterdischarges and compare the characteristics of afterdischarges in MG with different serum antibodies. Methods: Ninety-two patients with MG were analyzed retrospectively. The afterdis...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078411/ https://www.ncbi.nlm.nih.gov/pubmed/33927677 http://dx.doi.org/10.3389/fneur.2021.599744 |
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author | Yang, Li Guo, Shougang Chen, Xiuying |
author_facet | Yang, Li Guo, Shougang Chen, Xiuying |
author_sort | Yang, Li |
collection | PubMed |
description | Introduction: This study aimed to analyze the clinical features of myasthenia gravis (MG) in combination with the afterdischarges and compare the characteristics of afterdischarges in MG with different serum antibodies. Methods: Ninety-two patients with MG were analyzed retrospectively. The afterdischarges were investigated using motor nerve conduction examination, F-wave examination, and repetitive nerve stimulation (RNS). Results: Afterdischarges were observed after the M wave in 14 of 92 patients. Three of these 14 patients tested positive for the muscle-specific tyrosine kinase antibody (MuSK-Ab), and 11 patients tested positive for the acetylcholine receptor antibody (AchR-Ab). The characteristics of the afterdischarges on RNS differed distinctly between the two antibody groups. The afterdischarges occurred on the first stimulation, but decreased on the second and subsequent stimulations in patients with MuSK-MG, while the afterdischarges continued to occur on each stimulation in patients with AchR-MG. Discussion: The characteristics of the afterdischarges on RNS enabled easy identification of their synaptic or neurogenic nature. |
format | Online Article Text |
id | pubmed-8078411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80784112021-04-28 Afterdischarges in Myasthenia Gravis Yang, Li Guo, Shougang Chen, Xiuying Front Neurol Neurology Introduction: This study aimed to analyze the clinical features of myasthenia gravis (MG) in combination with the afterdischarges and compare the characteristics of afterdischarges in MG with different serum antibodies. Methods: Ninety-two patients with MG were analyzed retrospectively. The afterdischarges were investigated using motor nerve conduction examination, F-wave examination, and repetitive nerve stimulation (RNS). Results: Afterdischarges were observed after the M wave in 14 of 92 patients. Three of these 14 patients tested positive for the muscle-specific tyrosine kinase antibody (MuSK-Ab), and 11 patients tested positive for the acetylcholine receptor antibody (AchR-Ab). The characteristics of the afterdischarges on RNS differed distinctly between the two antibody groups. The afterdischarges occurred on the first stimulation, but decreased on the second and subsequent stimulations in patients with MuSK-MG, while the afterdischarges continued to occur on each stimulation in patients with AchR-MG. Discussion: The characteristics of the afterdischarges on RNS enabled easy identification of their synaptic or neurogenic nature. Frontiers Media S.A. 2021-04-13 /pmc/articles/PMC8078411/ /pubmed/33927677 http://dx.doi.org/10.3389/fneur.2021.599744 Text en Copyright © 2021 Yang, Guo and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Yang, Li Guo, Shougang Chen, Xiuying Afterdischarges in Myasthenia Gravis |
title | Afterdischarges in Myasthenia Gravis |
title_full | Afterdischarges in Myasthenia Gravis |
title_fullStr | Afterdischarges in Myasthenia Gravis |
title_full_unstemmed | Afterdischarges in Myasthenia Gravis |
title_short | Afterdischarges in Myasthenia Gravis |
title_sort | afterdischarges in myasthenia gravis |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078411/ https://www.ncbi.nlm.nih.gov/pubmed/33927677 http://dx.doi.org/10.3389/fneur.2021.599744 |
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