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The predictive value of serum procalcitonin for non-invasive positive pressure ventilation in the patients with acute exacerbation of chronic obstructive pulmonary disease
This study aimed to estimate the value of serum procalcitonin (PCT) for non-invasive positive pressure ventilation (NIPPV) prediction in the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 220 AECOPD patients were divided into NIPPV group (n = 121) and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078461/ https://www.ncbi.nlm.nih.gov/pubmed/33879703 http://dx.doi.org/10.1097/MD.0000000000025547 |
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author | Liu, Linlin Luan, Ying Xiao, Ling Wang, Ning Wang, Jing Cui, Zhaobo |
author_facet | Liu, Linlin Luan, Ying Xiao, Ling Wang, Ning Wang, Jing Cui, Zhaobo |
author_sort | Liu, Linlin |
collection | PubMed |
description | This study aimed to estimate the value of serum procalcitonin (PCT) for non-invasive positive pressure ventilation (NIPPV) prediction in the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 220 AECOPD patients were divided into NIPPV group (n = 121) and control group (routine treatment, n = 99) based on the routine standards and physicians’ experience. Logistic regression analysis was performed to identify the independent factors for NIPPV treatment. Additionally, the predictive values of the factors were measured through receiver operation characteristic (ROC) curve. NIPPV group and control group showed significant differences in respiratory rate (RR), PaO(2), PaCO(2), pH, oxygenation index, erythrocyte sedimentation rate (ESR), neutrophil, CRP (C-reaction protein), and PCT (P < .05 for all). PCT, CRP, PaCO(2), RR, and neutrophil were independently correlated with NIPPV treatment in AECOPD. ROC curve showed that PCT had superior predictive value, with AUC of 0.899, the sensitivity of 86%, and the specificity of 91.9%. The cut-off value of serum PCT for NIPPV prediction was 88.50 ng/l. AECOPD patients who require NIPPV treatment frequently have high levels of PCT, CRP, PaCO(2), RR and neutrophil. Serum PCT may be employed as an indicator for NIPPV treatment in AECOPD patients. |
format | Online Article Text |
id | pubmed-8078461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-80784612021-04-28 The predictive value of serum procalcitonin for non-invasive positive pressure ventilation in the patients with acute exacerbation of chronic obstructive pulmonary disease Liu, Linlin Luan, Ying Xiao, Ling Wang, Ning Wang, Jing Cui, Zhaobo Medicine (Baltimore) 6700 This study aimed to estimate the value of serum procalcitonin (PCT) for non-invasive positive pressure ventilation (NIPPV) prediction in the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 220 AECOPD patients were divided into NIPPV group (n = 121) and control group (routine treatment, n = 99) based on the routine standards and physicians’ experience. Logistic regression analysis was performed to identify the independent factors for NIPPV treatment. Additionally, the predictive values of the factors were measured through receiver operation characteristic (ROC) curve. NIPPV group and control group showed significant differences in respiratory rate (RR), PaO(2), PaCO(2), pH, oxygenation index, erythrocyte sedimentation rate (ESR), neutrophil, CRP (C-reaction protein), and PCT (P < .05 for all). PCT, CRP, PaCO(2), RR, and neutrophil were independently correlated with NIPPV treatment in AECOPD. ROC curve showed that PCT had superior predictive value, with AUC of 0.899, the sensitivity of 86%, and the specificity of 91.9%. The cut-off value of serum PCT for NIPPV prediction was 88.50 ng/l. AECOPD patients who require NIPPV treatment frequently have high levels of PCT, CRP, PaCO(2), RR and neutrophil. Serum PCT may be employed as an indicator for NIPPV treatment in AECOPD patients. Lippincott Williams & Wilkins 2021-04-23 /pmc/articles/PMC8078461/ /pubmed/33879703 http://dx.doi.org/10.1097/MD.0000000000025547 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 6700 Liu, Linlin Luan, Ying Xiao, Ling Wang, Ning Wang, Jing Cui, Zhaobo The predictive value of serum procalcitonin for non-invasive positive pressure ventilation in the patients with acute exacerbation of chronic obstructive pulmonary disease |
title | The predictive value of serum procalcitonin for non-invasive positive pressure ventilation in the patients with acute exacerbation of chronic obstructive pulmonary disease |
title_full | The predictive value of serum procalcitonin for non-invasive positive pressure ventilation in the patients with acute exacerbation of chronic obstructive pulmonary disease |
title_fullStr | The predictive value of serum procalcitonin for non-invasive positive pressure ventilation in the patients with acute exacerbation of chronic obstructive pulmonary disease |
title_full_unstemmed | The predictive value of serum procalcitonin for non-invasive positive pressure ventilation in the patients with acute exacerbation of chronic obstructive pulmonary disease |
title_short | The predictive value of serum procalcitonin for non-invasive positive pressure ventilation in the patients with acute exacerbation of chronic obstructive pulmonary disease |
title_sort | predictive value of serum procalcitonin for non-invasive positive pressure ventilation in the patients with acute exacerbation of chronic obstructive pulmonary disease |
topic | 6700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078461/ https://www.ncbi.nlm.nih.gov/pubmed/33879703 http://dx.doi.org/10.1097/MD.0000000000025547 |
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