Development of a mechanism of action-reflective, dual target cell-based reporter bioassay for a bispecific monoclonal antibody targeting human CTLA-4 and PD-1

T-cell-mediated immunotherapy has generated much excitement after the success of therapeutic biologics targeting immune checkpoint molecules. Bispecific antibodies (BsAbs) that recognize two antigen targets are a fast-growing class of biologics offering promising clinical benefits for cancer immunot...

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Detalles Bibliográficos
Autores principales: Chen, Weimin, Pandey, Madhu, Sun, Hong, Rolong, Andrea, Cao, Mingyan, Liu, Dengfeng, Wang, Jihong, Zeng, Lingmin, Hunter, Alan, Lin, Shihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078673/
https://www.ncbi.nlm.nih.gov/pubmed/33870864
http://dx.doi.org/10.1080/19420862.2021.1914359

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