Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is therapeutically recalcitrant and metastatic. Partial epithelial to mesenchymal transition (EMT) is associated with metastasis; however, a causal connection needs further unraveling. Here, we use single-cell RNA sequencing and genetic mouse models to identif...

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Detalles Bibliográficos
Autores principales: Carstens, Julienne L., Yang, Sujuan, Correa de Sampaio, Pedro, Zheng, Xiaofeng, Barua, Souptik, McAndrews, Kathleen M., Rao, Arvind, Burks, Jared K., Rhim, Andrew D., Kalluri, Raghu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078733/
https://www.ncbi.nlm.nih.gov/pubmed/33852841
http://dx.doi.org/10.1016/j.celrep.2021.108990

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