Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer

Topotecan is potent anti-cancer drug approved for various malignancies but hematopoietic toxicities undermine its wider application and use of its most effective dose. This study aims to improve these limitations through inhalation-delivery. The pharmacokinetics, efficacy, and toxicity of 2–5 times...

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Detalles Bibliográficos
Autores principales: Kuehl, Philip J., Yingling, Christin M., Dubose, Devon, Burke, Michael, Revelli, David A., Chen, Wenshu, Dye, Wendy W., Belinsky, Steven A., Tessema, Mathewos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079036/
https://www.ncbi.nlm.nih.gov/pubmed/33860729
http://dx.doi.org/10.1080/10717544.2021.1912209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079036/
https://www.ncbi.nlm.nih.gov/pubmed/33860729
http://dx.doi.org/10.1080/10717544.2021.1912209

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