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Transient kinetic studies of the antiviral Drosophila Dicer-2 reveal roles of ATP in self–nonself discrimination

Some RIG-I-like receptors (RLRs) discriminate viral and cellular dsRNA by their termini, and Drosophila melanogaster Dicer-2 (dmDcr-2) differentially processes dsRNA with blunt or 2 nucleotide 3’-overhanging termini. We investigated the transient kinetic mechanism of the dmDcr-2 reaction using a rap...

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Detalles Bibliográficos
Autores principales:	Singh, Raushan K, Jonely, McKenzie, Leslie, Evan, Rejali, Nick A, Noriega, Rodrigo, Bass, Brenda L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079148/ https://www.ncbi.nlm.nih.gov/pubmed/33787495 http://dx.doi.org/10.7554/eLife.65810

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