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The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study
PURPOSE: Obstructive sleep apnea (OSA) may increase the risk of severe COVID-19; however, the level of potential modulation has not yet been established. The objective of the study was to determine the association between high risk of OSA, comorbidities, and increased risk for COVID-19, hospitalizat...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079162/ https://www.ncbi.nlm.nih.gov/pubmed/33907966 http://dx.doi.org/10.1007/s11325-021-02373-5 |
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author | Chung, Frances Waseem, Rida Pham, Chi Penzel, Thomas Han, Fang Bjorvatn, Bjørn Morin, Charles M. Holzinger, Brigitte Espie, Colin A. Benedict, Christian Cedernaes, Jonathan Saaresranta, Tarja Wing, Yun Kwok Nadorff, Michael R. Dauvilliers, Yves De Gennaro, Luigi Plazzi, Guiseppe Merikanto, Ilona Matsui, Kentaro Leger, Damien Sieminski, Mariusz Mota-Rolim, Sergio Inoue, Yuichi Partinen, Markku |
author_facet | Chung, Frances Waseem, Rida Pham, Chi Penzel, Thomas Han, Fang Bjorvatn, Bjørn Morin, Charles M. Holzinger, Brigitte Espie, Colin A. Benedict, Christian Cedernaes, Jonathan Saaresranta, Tarja Wing, Yun Kwok Nadorff, Michael R. Dauvilliers, Yves De Gennaro, Luigi Plazzi, Guiseppe Merikanto, Ilona Matsui, Kentaro Leger, Damien Sieminski, Mariusz Mota-Rolim, Sergio Inoue, Yuichi Partinen, Markku |
author_sort | Chung, Frances |
collection | PubMed |
description | PURPOSE: Obstructive sleep apnea (OSA) may increase the risk of severe COVID-19; however, the level of potential modulation has not yet been established. The objective of the study was to determine the association between high risk of OSA, comorbidities, and increased risk for COVID-19, hospitalization, and intensive care unit (ICU) treatment. METHODS: We conducted a cross-sectional population-based web survey in adults in 14 countries/regions. The survey included sociodemographic variables and comorbidities. Participants were asked questions about COVID-19, hospitalization, and ICU treatment. Standardized questionnaire (STOP questionnaire for high risk of OSA) was included. Multivariable logistic regression was conducted adjusting for various factors. RESULTS: Out of 26,539 respondents, 20,598 (35.4% male) completed the survey. Mean age and BMI of participants were 41.5 ± 16.0 years and 24.0 ± 5.0 kg/m(2), respectively. The prevalence of physician-diagnosed OSA was 4.1% and high risk of OSA was 9.5%. We found that high risk of OSA (adjusted odds ratio (aOR) 1.72, 95% confidence interval (CI): 1.20, 2.47) and diabetes (aOR 2.07, 95% CI: 1.23, 3.48) were associated with reporting of a COVID-19 diagnosis. High risk for OSA (aOR 2.11, 95% CI: 1.10–4.01), being male (aOR: 2.82, 95% CI: 1.55–5.12), having diabetes (aOR: 3.93, 95% CI: 1.70–9.12), and having depression (aOR: 2.33, 95% CI: 1.15–4.77) were associated with increased risk of hospitalization or ICU treatment. CONCLUSIONS: Participants at high risk of OSA had increased odds of having COVID-19 and were two times more likely to be hospitalized or treated in ICU. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11325-021-02373-5. |
format | Online Article Text |
id | pubmed-8079162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-80791622021-04-28 The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study Chung, Frances Waseem, Rida Pham, Chi Penzel, Thomas Han, Fang Bjorvatn, Bjørn Morin, Charles M. Holzinger, Brigitte Espie, Colin A. Benedict, Christian Cedernaes, Jonathan Saaresranta, Tarja Wing, Yun Kwok Nadorff, Michael R. Dauvilliers, Yves De Gennaro, Luigi Plazzi, Guiseppe Merikanto, Ilona Matsui, Kentaro Leger, Damien Sieminski, Mariusz Mota-Rolim, Sergio Inoue, Yuichi Partinen, Markku Sleep Breath Sleep Breathing Physiology and Disorders • Original Article PURPOSE: Obstructive sleep apnea (OSA) may increase the risk of severe COVID-19; however, the level of potential modulation has not yet been established. The objective of the study was to determine the association between high risk of OSA, comorbidities, and increased risk for COVID-19, hospitalization, and intensive care unit (ICU) treatment. METHODS: We conducted a cross-sectional population-based web survey in adults in 14 countries/regions. The survey included sociodemographic variables and comorbidities. Participants were asked questions about COVID-19, hospitalization, and ICU treatment. Standardized questionnaire (STOP questionnaire for high risk of OSA) was included. Multivariable logistic regression was conducted adjusting for various factors. RESULTS: Out of 26,539 respondents, 20,598 (35.4% male) completed the survey. Mean age and BMI of participants were 41.5 ± 16.0 years and 24.0 ± 5.0 kg/m(2), respectively. The prevalence of physician-diagnosed OSA was 4.1% and high risk of OSA was 9.5%. We found that high risk of OSA (adjusted odds ratio (aOR) 1.72, 95% confidence interval (CI): 1.20, 2.47) and diabetes (aOR 2.07, 95% CI: 1.23, 3.48) were associated with reporting of a COVID-19 diagnosis. High risk for OSA (aOR 2.11, 95% CI: 1.10–4.01), being male (aOR: 2.82, 95% CI: 1.55–5.12), having diabetes (aOR: 3.93, 95% CI: 1.70–9.12), and having depression (aOR: 2.33, 95% CI: 1.15–4.77) were associated with increased risk of hospitalization or ICU treatment. CONCLUSIONS: Participants at high risk of OSA had increased odds of having COVID-19 and were two times more likely to be hospitalized or treated in ICU. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11325-021-02373-5. Springer International Publishing 2021-04-28 2021 /pmc/articles/PMC8079162/ /pubmed/33907966 http://dx.doi.org/10.1007/s11325-021-02373-5 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Sleep Breathing Physiology and Disorders • Original Article Chung, Frances Waseem, Rida Pham, Chi Penzel, Thomas Han, Fang Bjorvatn, Bjørn Morin, Charles M. Holzinger, Brigitte Espie, Colin A. Benedict, Christian Cedernaes, Jonathan Saaresranta, Tarja Wing, Yun Kwok Nadorff, Michael R. Dauvilliers, Yves De Gennaro, Luigi Plazzi, Guiseppe Merikanto, Ilona Matsui, Kentaro Leger, Damien Sieminski, Mariusz Mota-Rolim, Sergio Inoue, Yuichi Partinen, Markku The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study |
title | The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study |
title_full | The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study |
title_fullStr | The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study |
title_full_unstemmed | The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study |
title_short | The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study |
title_sort | association between high risk of sleep apnea, comorbidities, and risk of covid-19: a population-based international harmonized study |
topic | Sleep Breathing Physiology and Disorders • Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079162/ https://www.ncbi.nlm.nih.gov/pubmed/33907966 http://dx.doi.org/10.1007/s11325-021-02373-5 |
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