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The Formidable yet Unresolved Interplay between Endometriosis and Obesity

Obesity and endometriosis are two very common entities, yet there is uncertainty on their exact relationship. Observational studies have repeatedly shown an inverse correlation between endometriosis and a low body mass index (BMI). However, obesity does not protect against endometriosis and on the c...

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Autores principales: Pantelis, Athanasios, Machairiotis, Nikolaos, Lapatsanis, Dimitris P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079185/
https://www.ncbi.nlm.nih.gov/pubmed/33986637
http://dx.doi.org/10.1155/2021/6653677
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author Pantelis, Athanasios
Machairiotis, Nikolaos
Lapatsanis, Dimitris P.
author_facet Pantelis, Athanasios
Machairiotis, Nikolaos
Lapatsanis, Dimitris P.
author_sort Pantelis, Athanasios
collection PubMed
description Obesity and endometriosis are two very common entities, yet there is uncertainty on their exact relationship. Observational studies have repeatedly shown an inverse correlation between endometriosis and a low body mass index (BMI). However, obesity does not protect against endometriosis and on the contrary an increased BMI may lead to more severe forms of the disease. Besides, BMI is not accurate in all cases of obesity. Consequently, other anthropometric and phenomic traits have been studied, including body adiposity content, as well as the effect of BMI early in life on the manifestation of endometriosis in adulthood. Some studies have shown that the phenotypic inverse correlation between the two entities has a genetic background; however, others have indicated that certain polymorphisms are linked with endometriosis in females with increased BMI. The advent of metabolic bariatric surgery and pertinent research have led to the emergence of biomolecules that may be pivotal in understanding the pathophysiological interaction of the two entities, especially in the context of angiogenesis and inflammation. Future research should focus on three objectives: detection and interpretation of obesity-related biomarkers in experimental models with endometriosis; integration of endometriosis-related queries into bariatric registries; and multidisciplinary approach and collaboration among specialists.
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spelling pubmed-80791852021-05-12 The Formidable yet Unresolved Interplay between Endometriosis and Obesity Pantelis, Athanasios Machairiotis, Nikolaos Lapatsanis, Dimitris P. ScientificWorldJournal Review Article Obesity and endometriosis are two very common entities, yet there is uncertainty on their exact relationship. Observational studies have repeatedly shown an inverse correlation between endometriosis and a low body mass index (BMI). However, obesity does not protect against endometriosis and on the contrary an increased BMI may lead to more severe forms of the disease. Besides, BMI is not accurate in all cases of obesity. Consequently, other anthropometric and phenomic traits have been studied, including body adiposity content, as well as the effect of BMI early in life on the manifestation of endometriosis in adulthood. Some studies have shown that the phenotypic inverse correlation between the two entities has a genetic background; however, others have indicated that certain polymorphisms are linked with endometriosis in females with increased BMI. The advent of metabolic bariatric surgery and pertinent research have led to the emergence of biomolecules that may be pivotal in understanding the pathophysiological interaction of the two entities, especially in the context of angiogenesis and inflammation. Future research should focus on three objectives: detection and interpretation of obesity-related biomarkers in experimental models with endometriosis; integration of endometriosis-related queries into bariatric registries; and multidisciplinary approach and collaboration among specialists. Hindawi 2021-04-20 /pmc/articles/PMC8079185/ /pubmed/33986637 http://dx.doi.org/10.1155/2021/6653677 Text en Copyright © 2021 Athanasios Pantelis et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pantelis, Athanasios
Machairiotis, Nikolaos
Lapatsanis, Dimitris P.
The Formidable yet Unresolved Interplay between Endometriosis and Obesity
title The Formidable yet Unresolved Interplay between Endometriosis and Obesity
title_full The Formidable yet Unresolved Interplay between Endometriosis and Obesity
title_fullStr The Formidable yet Unresolved Interplay between Endometriosis and Obesity
title_full_unstemmed The Formidable yet Unresolved Interplay between Endometriosis and Obesity
title_short The Formidable yet Unresolved Interplay between Endometriosis and Obesity
title_sort formidable yet unresolved interplay between endometriosis and obesity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079185/
https://www.ncbi.nlm.nih.gov/pubmed/33986637
http://dx.doi.org/10.1155/2021/6653677
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