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CRISPR-edited CART with GM-CSF knockout and auto secretion of IL6 and IL1 blockers in patients with hematologic malignancy

Revolutionary CART therapy still faces the challenge of severe cytokine release syndrome (CRS). While IL6 and IL1 have been demonstrated as essential contributors, GM-CSF is one of the most abundant inflammatory cytokines secreted by CART and has also been suggested in contributing to CRS. To minimi...

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Detalles Bibliográficos
Autores principales:	Yi, Yan, Chai, Xiaoshan, Zheng, Liping, Zhang, Yongjing, Shen, Jiankai, Hu, Biliang, Tao, Guangshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079381/ https://www.ncbi.nlm.nih.gov/pubmed/33907185 http://dx.doi.org/10.1038/s41421-021-00255-4

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