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Computed Tomography-Guided Methylene Blue Localization: Single vs. Multiple Lung Nodules
Background: Preoperative localization for small invisible and impalpable pulmonary nodules is important in single-port video-assisted thoracoscopic surgery (VATS). Localization of multiple pulmonary nodules during VATS resection remains challenging. The aim of our study is to elucidate the efficacy...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079624/ https://www.ncbi.nlm.nih.gov/pubmed/33937298 http://dx.doi.org/10.3389/fmed.2021.661956 |
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author | Lin, Chia-Ying Chang, Chao-Chun Huang, Li-Ting Chung, Ta-Jung Liu, Yi-Sheng Yen, Yi-Ting Tseng, Yau-Lin |
author_facet | Lin, Chia-Ying Chang, Chao-Chun Huang, Li-Ting Chung, Ta-Jung Liu, Yi-Sheng Yen, Yi-Ting Tseng, Yau-Lin |
author_sort | Lin, Chia-Ying |
collection | PubMed |
description | Background: Preoperative localization for small invisible and impalpable pulmonary nodules is important in single-port video-assisted thoracoscopic surgery (VATS). Localization of multiple pulmonary nodules during VATS resection remains challenging. The aim of our study is to elucidate the efficacy of preoperative CT-guided methylene blue localization of both single and multiple pulmonary nodules. Methods: Consecutive patients undergoing preoperative CT-guided methylene blue dye localization for lung nodules, followed by VATS resection, were retrospectively analyzed between January 2014 and November 2019. Chi-square tests, Fisher's exact test and independent T-test were used to compare variables between the groups. Logistic regression was used to identify risk factors for procedure-related complications. Results: A total of 388 patients, including 337 with single nodule and 51 with multiple nodules, were analyzed. The success rate of preoperative CT-guided methylene blue localization for both single and multiple pulmonary nodules were comparable as 98.8% (333/337) vs. 100% (108/108). The procedure time was longer (23.2 ± 9.4 vs. 7.6 ± 4.8 min, p < 0.001) and risk of pneumothorax was higher (47.1 vs. 25.5%, p = 0.002) in the multiple nodule group. The procedure time (OR 1.079; 95% CI = 1.041–1.118; p < 0.001) was an independent risk factor for pneumothorax. Nodule depth (OR 2.829; 95% CI = 1.259–6.356; p = 0.011) was an independent risk factor for pulmonary hemorrhage. Conclusions: Preoperative CT-guided methylene blue localization for both single and multiple pulmonary nodules is safe, feasible, and effective. |
format | Online Article Text |
id | pubmed-8079624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80796242021-04-29 Computed Tomography-Guided Methylene Blue Localization: Single vs. Multiple Lung Nodules Lin, Chia-Ying Chang, Chao-Chun Huang, Li-Ting Chung, Ta-Jung Liu, Yi-Sheng Yen, Yi-Ting Tseng, Yau-Lin Front Med (Lausanne) Medicine Background: Preoperative localization for small invisible and impalpable pulmonary nodules is important in single-port video-assisted thoracoscopic surgery (VATS). Localization of multiple pulmonary nodules during VATS resection remains challenging. The aim of our study is to elucidate the efficacy of preoperative CT-guided methylene blue localization of both single and multiple pulmonary nodules. Methods: Consecutive patients undergoing preoperative CT-guided methylene blue dye localization for lung nodules, followed by VATS resection, were retrospectively analyzed between January 2014 and November 2019. Chi-square tests, Fisher's exact test and independent T-test were used to compare variables between the groups. Logistic regression was used to identify risk factors for procedure-related complications. Results: A total of 388 patients, including 337 with single nodule and 51 with multiple nodules, were analyzed. The success rate of preoperative CT-guided methylene blue localization for both single and multiple pulmonary nodules were comparable as 98.8% (333/337) vs. 100% (108/108). The procedure time was longer (23.2 ± 9.4 vs. 7.6 ± 4.8 min, p < 0.001) and risk of pneumothorax was higher (47.1 vs. 25.5%, p = 0.002) in the multiple nodule group. The procedure time (OR 1.079; 95% CI = 1.041–1.118; p < 0.001) was an independent risk factor for pneumothorax. Nodule depth (OR 2.829; 95% CI = 1.259–6.356; p = 0.011) was an independent risk factor for pulmonary hemorrhage. Conclusions: Preoperative CT-guided methylene blue localization for both single and multiple pulmonary nodules is safe, feasible, and effective. Frontiers Media S.A. 2021-04-14 /pmc/articles/PMC8079624/ /pubmed/33937298 http://dx.doi.org/10.3389/fmed.2021.661956 Text en Copyright © 2021 Lin, Chang, Huang, Chung, Liu, Yen and Tseng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Lin, Chia-Ying Chang, Chao-Chun Huang, Li-Ting Chung, Ta-Jung Liu, Yi-Sheng Yen, Yi-Ting Tseng, Yau-Lin Computed Tomography-Guided Methylene Blue Localization: Single vs. Multiple Lung Nodules |
title | Computed Tomography-Guided Methylene Blue Localization: Single vs. Multiple Lung Nodules |
title_full | Computed Tomography-Guided Methylene Blue Localization: Single vs. Multiple Lung Nodules |
title_fullStr | Computed Tomography-Guided Methylene Blue Localization: Single vs. Multiple Lung Nodules |
title_full_unstemmed | Computed Tomography-Guided Methylene Blue Localization: Single vs. Multiple Lung Nodules |
title_short | Computed Tomography-Guided Methylene Blue Localization: Single vs. Multiple Lung Nodules |
title_sort | computed tomography-guided methylene blue localization: single vs. multiple lung nodules |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079624/ https://www.ncbi.nlm.nih.gov/pubmed/33937298 http://dx.doi.org/10.3389/fmed.2021.661956 |
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