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The Association Between Folate and Alzheimer's Disease: A Systematic Review and Meta-Analysis

Alzheimer's disease (AD) is the most common type of neurodegenerative disease leading to dementia in the elderly. Increasing evidence indicates that folate plays an important role in the pathogenesis of AD. To investigate the role of folate deficiency/possible deficiency in the risk of AD and t...

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Autores principales: Zhang, Xiaohong, Bao, Guangyi, Liu, Debiao, Yang, Yu, Li, Xuezhi, Cai, Gaomei, Liu, Yan, Wu, Yili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079632/
https://www.ncbi.nlm.nih.gov/pubmed/33935641
http://dx.doi.org/10.3389/fnins.2021.661198
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author Zhang, Xiaohong
Bao, Guangyi
Liu, Debiao
Yang, Yu
Li, Xuezhi
Cai, Gaomei
Liu, Yan
Wu, Yili
author_facet Zhang, Xiaohong
Bao, Guangyi
Liu, Debiao
Yang, Yu
Li, Xuezhi
Cai, Gaomei
Liu, Yan
Wu, Yili
author_sort Zhang, Xiaohong
collection PubMed
description Alzheimer's disease (AD) is the most common type of neurodegenerative disease leading to dementia in the elderly. Increasing evidence indicates that folate plays an important role in the pathogenesis of AD. To investigate the role of folate deficiency/possible deficiency in the risk of AD and the benefical effect of sufficient folate intake on the prevention of AD, a systematic review and meta-analysis were performed. The Web of Science, PubMed, CENTRAL, EBSCO, CNKI, CQVIP, and Wanfang databases were searched. The analysis of cross-sectional studies showed that the standardized mean difference (SMD) was −0.60 (95% confidence interval (CI): −0.65, −0.55), indicating that plasma/serum folate level is lower in AD patients than that in controls. Moreover, the combined odds ratio (OR) of case-control studies was 0.96 (95% CI: 0.93, 0.99), while the combined ORs were 0.86 (95% CI: 0.46, 1.26) and 1.94 (95% CI: 1.02, 2.86) in populations with normal levels of folate (≥13.5 nmol/L) and folate deficiency/possible deficiency (<13.5 nmol/L), respectively. In addition, the risk ratio (RR) of the cohort studies was 1.88 (95% CI: 1.20, 2.57) in populations with folate deficiency/possible deficiency. Furthermore, when the intake of folate was equal to or higher than the recommended daily allowance, the combined RR and hazard ratio (HR) were 0.44 (95% CI: 0.18, 0.71) and 0.76 (95% CI: 0.52, 0.99), respectively. These results indicate that folate deficiency/possible deficiency increases the risk for AD, while sufficient intake of folate is a protective factor against AD.
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spelling pubmed-80796322021-04-29 The Association Between Folate and Alzheimer's Disease: A Systematic Review and Meta-Analysis Zhang, Xiaohong Bao, Guangyi Liu, Debiao Yang, Yu Li, Xuezhi Cai, Gaomei Liu, Yan Wu, Yili Front Neurosci Neuroscience Alzheimer's disease (AD) is the most common type of neurodegenerative disease leading to dementia in the elderly. Increasing evidence indicates that folate plays an important role in the pathogenesis of AD. To investigate the role of folate deficiency/possible deficiency in the risk of AD and the benefical effect of sufficient folate intake on the prevention of AD, a systematic review and meta-analysis were performed. The Web of Science, PubMed, CENTRAL, EBSCO, CNKI, CQVIP, and Wanfang databases were searched. The analysis of cross-sectional studies showed that the standardized mean difference (SMD) was −0.60 (95% confidence interval (CI): −0.65, −0.55), indicating that plasma/serum folate level is lower in AD patients than that in controls. Moreover, the combined odds ratio (OR) of case-control studies was 0.96 (95% CI: 0.93, 0.99), while the combined ORs were 0.86 (95% CI: 0.46, 1.26) and 1.94 (95% CI: 1.02, 2.86) in populations with normal levels of folate (≥13.5 nmol/L) and folate deficiency/possible deficiency (<13.5 nmol/L), respectively. In addition, the risk ratio (RR) of the cohort studies was 1.88 (95% CI: 1.20, 2.57) in populations with folate deficiency/possible deficiency. Furthermore, when the intake of folate was equal to or higher than the recommended daily allowance, the combined RR and hazard ratio (HR) were 0.44 (95% CI: 0.18, 0.71) and 0.76 (95% CI: 0.52, 0.99), respectively. These results indicate that folate deficiency/possible deficiency increases the risk for AD, while sufficient intake of folate is a protective factor against AD. Frontiers Media S.A. 2021-04-14 /pmc/articles/PMC8079632/ /pubmed/33935641 http://dx.doi.org/10.3389/fnins.2021.661198 Text en Copyright © 2021 Zhang, Bao, Liu, Yang, Li, Cai, Liu and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Xiaohong
Bao, Guangyi
Liu, Debiao
Yang, Yu
Li, Xuezhi
Cai, Gaomei
Liu, Yan
Wu, Yili
The Association Between Folate and Alzheimer's Disease: A Systematic Review and Meta-Analysis
title The Association Between Folate and Alzheimer's Disease: A Systematic Review and Meta-Analysis
title_full The Association Between Folate and Alzheimer's Disease: A Systematic Review and Meta-Analysis
title_fullStr The Association Between Folate and Alzheimer's Disease: A Systematic Review and Meta-Analysis
title_full_unstemmed The Association Between Folate and Alzheimer's Disease: A Systematic Review and Meta-Analysis
title_short The Association Between Folate and Alzheimer's Disease: A Systematic Review and Meta-Analysis
title_sort association between folate and alzheimer's disease: a systematic review and meta-analysis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079632/
https://www.ncbi.nlm.nih.gov/pubmed/33935641
http://dx.doi.org/10.3389/fnins.2021.661198
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