Cargando…

Exercise Training-Increased FBXO32 and FOXO1 in a Gender-Dependent Manner in Mild Cognitively Impaired African Americans: GEMS-1 Study

The ubiquitin proteasome system (UPS) and FOXOs transcription factors play a pivotal role in cellular clearance and minimizing the accumulation of Aβ in neurodegeneration (ND). In African Americans (AAs) with mild cognitive impairment (MCI), the role of components of UPS and FOXOs; and whether they...

Descripción completa

Detalles Bibliográficos
Autores principales: Bedada, Fikru B., Ntekim, Oyonumo E., Nwulia, Evaristus O., Fungwe, Thomas V., Nadarajah, Sheeba Raaj, Obisesan, Thomas O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079639/
https://www.ncbi.nlm.nih.gov/pubmed/33935685
http://dx.doi.org/10.3389/fnagi.2021.641758
_version_ 1783685252219142144
author Bedada, Fikru B.
Ntekim, Oyonumo E.
Nwulia, Evaristus O.
Fungwe, Thomas V.
Nadarajah, Sheeba Raaj
Obisesan, Thomas O.
author_facet Bedada, Fikru B.
Ntekim, Oyonumo E.
Nwulia, Evaristus O.
Fungwe, Thomas V.
Nadarajah, Sheeba Raaj
Obisesan, Thomas O.
author_sort Bedada, Fikru B.
collection PubMed
description The ubiquitin proteasome system (UPS) and FOXOs transcription factors play a pivotal role in cellular clearance and minimizing the accumulation of Aβ in neurodegeneration (ND). In African Americans (AAs) with mild cognitive impairment (MCI), the role of components of UPS and FOXOs; and whether they are amenable to exercise effects is unknown. We hypothesized that exercise can enhance cellular clearance systems during aging and ND by increasing expressions of FBXO32 and FOXO1. To test this hypothesis, we used TaqMan gene expression analysis in peripheral blood (PB) to investigate the component of UPS and FOXOs; and provide mechanistic insight at baseline, during exercise, and in both genders. At baseline, levels of FBXO32 were higher in women than in men. In our attempt to discern gender-specific exercise-related changes, we observed that levels of FBXO32 increased in men but not in women. Similarly, levels of FOXO1 increased in men only. These data suggest that a graded dose of FBXO32 and FOXO1 may be beneficial when PB cells carrying FBXO32 and FOXO1 summon into the brain in response to Alzheimer’s disease (AD) perturbation (docking station PB cells). Our observation is consistent with emerging studies that exercise allows the trafficking of blood factors. Given the significance of FBXO32 and FOXO1 to ND and associated muscle integrity, our findings may explain, at least in part, the benefits of exercise on memory, associated gait, and balance perturbation acknowledged to herald the emergence of MCI.
format Online
Article
Text
id pubmed-8079639
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80796392021-04-29 Exercise Training-Increased FBXO32 and FOXO1 in a Gender-Dependent Manner in Mild Cognitively Impaired African Americans: GEMS-1 Study Bedada, Fikru B. Ntekim, Oyonumo E. Nwulia, Evaristus O. Fungwe, Thomas V. Nadarajah, Sheeba Raaj Obisesan, Thomas O. Front Aging Neurosci Neuroscience The ubiquitin proteasome system (UPS) and FOXOs transcription factors play a pivotal role in cellular clearance and minimizing the accumulation of Aβ in neurodegeneration (ND). In African Americans (AAs) with mild cognitive impairment (MCI), the role of components of UPS and FOXOs; and whether they are amenable to exercise effects is unknown. We hypothesized that exercise can enhance cellular clearance systems during aging and ND by increasing expressions of FBXO32 and FOXO1. To test this hypothesis, we used TaqMan gene expression analysis in peripheral blood (PB) to investigate the component of UPS and FOXOs; and provide mechanistic insight at baseline, during exercise, and in both genders. At baseline, levels of FBXO32 were higher in women than in men. In our attempt to discern gender-specific exercise-related changes, we observed that levels of FBXO32 increased in men but not in women. Similarly, levels of FOXO1 increased in men only. These data suggest that a graded dose of FBXO32 and FOXO1 may be beneficial when PB cells carrying FBXO32 and FOXO1 summon into the brain in response to Alzheimer’s disease (AD) perturbation (docking station PB cells). Our observation is consistent with emerging studies that exercise allows the trafficking of blood factors. Given the significance of FBXO32 and FOXO1 to ND and associated muscle integrity, our findings may explain, at least in part, the benefits of exercise on memory, associated gait, and balance perturbation acknowledged to herald the emergence of MCI. Frontiers Media S.A. 2021-04-14 /pmc/articles/PMC8079639/ /pubmed/33935685 http://dx.doi.org/10.3389/fnagi.2021.641758 Text en Copyright © 2021 Bedada, Ntekim, Nwulia, Fungwe, Nadarajah and Obisesan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Bedada, Fikru B.
Ntekim, Oyonumo E.
Nwulia, Evaristus O.
Fungwe, Thomas V.
Nadarajah, Sheeba Raaj
Obisesan, Thomas O.
Exercise Training-Increased FBXO32 and FOXO1 in a Gender-Dependent Manner in Mild Cognitively Impaired African Americans: GEMS-1 Study
title Exercise Training-Increased FBXO32 and FOXO1 in a Gender-Dependent Manner in Mild Cognitively Impaired African Americans: GEMS-1 Study
title_full Exercise Training-Increased FBXO32 and FOXO1 in a Gender-Dependent Manner in Mild Cognitively Impaired African Americans: GEMS-1 Study
title_fullStr Exercise Training-Increased FBXO32 and FOXO1 in a Gender-Dependent Manner in Mild Cognitively Impaired African Americans: GEMS-1 Study
title_full_unstemmed Exercise Training-Increased FBXO32 and FOXO1 in a Gender-Dependent Manner in Mild Cognitively Impaired African Americans: GEMS-1 Study
title_short Exercise Training-Increased FBXO32 and FOXO1 in a Gender-Dependent Manner in Mild Cognitively Impaired African Americans: GEMS-1 Study
title_sort exercise training-increased fbxo32 and foxo1 in a gender-dependent manner in mild cognitively impaired african americans: gems-1 study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079639/
https://www.ncbi.nlm.nih.gov/pubmed/33935685
http://dx.doi.org/10.3389/fnagi.2021.641758
work_keys_str_mv AT bedadafikrub exercisetrainingincreasedfbxo32andfoxo1inagenderdependentmannerinmildcognitivelyimpairedafricanamericansgems1study
AT ntekimoyonumoe exercisetrainingincreasedfbxo32andfoxo1inagenderdependentmannerinmildcognitivelyimpairedafricanamericansgems1study
AT nwuliaevaristuso exercisetrainingincreasedfbxo32andfoxo1inagenderdependentmannerinmildcognitivelyimpairedafricanamericansgems1study
AT fungwethomasv exercisetrainingincreasedfbxo32andfoxo1inagenderdependentmannerinmildcognitivelyimpairedafricanamericansgems1study
AT nadarajahsheebaraaj exercisetrainingincreasedfbxo32andfoxo1inagenderdependentmannerinmildcognitivelyimpairedafricanamericansgems1study
AT obisesanthomaso exercisetrainingincreasedfbxo32andfoxo1inagenderdependentmannerinmildcognitivelyimpairedafricanamericansgems1study