Cargando…

Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease

White matter (WM) alterations have been identified as a relevant pathological feature of Huntington’s disease (HD). Increasing evidence suggests that WM changes in this disorder are due to alterations in myelin‐associated biological processes. Multi-compartmental analysis of the complex gradient-ech...

Descripción completa

Detalles Bibliográficos
Autores principales:	Casella, Chiara, Kleban, Elena, Rosser, Anne E., Coulthard, Elizabeth, Rickards, Hugh, Fasano, Fabrizio, Metzler-Baddeley, Claudia, Jones, Derek K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079666/ https://www.ncbi.nlm.nih.gov/pubmed/33865029 http://dx.doi.org/10.1016/j.nicl.2021.102658

Ejemplares similares

Mutation‐related magnetization‐transfer, not axon density, drives white matter differences in premanifest Huntington disease: Evidence from in vivo ultra‐strong gradient MRI
por: Casella, Chiara, et al.
Publicado: (2022)

Myelin Breakdown in Human Huntington’s Disease: Multi-Modal Evidence from Diffusion MRI and Quantitative Magnetization Transfer
por: Bourbon-Teles, José, et al.
Publicado: (2019)

Drumming Motor Sequence Training Induces Apparent Myelin Remodelling in Huntington’s Disease: A Longitudinal Diffusion MRI and Quantitative Magnetization Transfer Study
por: Casella, Chiara, et al.
Publicado: (2020)

Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington’s Disease
por: Collins, Lucy M., et al.
Publicado: (2015)

Magnetization transfer imaging in ‘premanifest’ Huntington’s disease
por: Jurgens, Caroline K., et al.
Publicado: (2009)

Peripheral Biomarkers in Manifest and Premanifest Huntington’s Disease
por: Morena, Emanuele, et al.
Publicado: (2023)

A Critical Review of White Matter Changes in Huntington’s Disease
por: Casella, Chiara, et al.
Publicado: (2020)

Sleep deficits but no metabolic deficits in premanifest Huntington's disease
por: Lazar, Alpar S., et al.
Publicado: (2015)

MRI T2 Hypointensities in basal ganglia of premanifest Huntington's disease
por: Jurgens, Caroline K, et al.
Publicado: (2010)

White matter predicts functional connectivity in premanifest Huntington's disease
por: McColgan, Peter, et al.
Publicado: (2017)

Premanifest Huntington’s disease: Examination of oculomotor abnormalities in clinical practice
por: Winder, Jessica Y., et al.
Publicado: (2018)

Testing a longitudinal compensation model in premanifest Huntington’s disease
por: Gregory, Sarah, et al.
Publicado: (2018)

In vivo characterization of white matter pathology in premanifest huntington's disease
por: Zhang, Jiaying, et al.
Publicado: (2018)

Computerised Dynamic Posturography in Premanifest and Manifest individuals with Huntington’s Disease
por: Reyes, Alvaro, et al.
Publicado: (2018)

Visual Object Perception in Premanifest and Early Manifest Huntington’s Disease
por: Coppen, Emma M, et al.
Publicado: (2019)

Time will tell: Decision making in premanifest and manifest Huntington’s disease
por: Heim, Beatrice, et al.
Publicado: (2020)

Seven-year clinical follow-up of premanifest carriers of Huntington's disease
por: Hart, Ellen, et al.
Publicado: (2011)

Abnormal Electrophysiological Motor Responses in Huntington’s Disease: Evidence of Premanifest Compensation
por: Turner, Lauren M., et al.
Publicado: (2015)

Safer Attitude to Risky Decision-Making in Premanifest Huntington’s Disease Subjects
por: D’Aurizio, Giulia, et al.
Publicado: (2019)

Revealing the Timeline of Structural MRI Changes in Premanifest to Manifest Huntington Disease
por: Wijeratne, Peter A., et al.
Publicado: (2021)

Linking white matter and deep gray matter alterations in premanifest Huntington disease
por: Faria, Andreia V., et al.
Publicado: (2016)

Baseline multimodal information predicts future motor impairment in premanifest Huntington's disease
por: Castro, Eduardo, et al.
Publicado: (2018)

Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease
por: McColgan, Peter, et al.
Publicado: (2017)

Timing of selective basal ganglia white matter loss in premanifest Huntington’s disease
por: Zeun, Paul, et al.
Publicado: (2022)

Strong diffusion gradients allow the separation of intra- and extra-axonal gradient-echo signals in the human brain
por: Kleban, Elena, et al.
Publicado: (2020)

Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease
por: Stout, Julie C, et al.
Publicado: (2012)

Body composition in premanifest Huntington’s disease reveals lower bone density compared to controls.
por: Goodman, Anna O. G., et al.
Publicado: (2011)

Topological length of white matter connections predicts their rate of atrophy in premanifest Huntington’s disease
por: McColgan, Peter, et al.
Publicado: (2017)

Resting-state connectivity stratifies premanifest Huntington’s disease by longitudinal cognitive decline rate
por: Polosecki, Pablo, et al.
Publicado: (2020)

The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington’s disease individuals
por: Júlio, Filipa, et al.
Publicado: (2019)

Hair and salivary cortisol and their relationship with lifestyle, mood and cognitive outcomes in premanifest Huntington’s disease
por: Cruickshank, Travis, et al.
Publicado: (2021)

The relationship between non-motor features and weight-loss in the premanifest stage of Huntington’s disease
por: Khan, Wasiq, et al.
Publicado: (2021)

Spatiotemporal Gait Parameters in Adults With Premanifest and Manifest Huntington’s Disease: A Systematic Review
por: Browning, Sasha, et al.
Publicado: (2023)

Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study
por: Johnson, Eileanoir B., et al.
Publicado: (2021)

A novel cognitive-neurophysiological state biomarker in premanifest Huntington's disease validated on longitudinal data
por: Beste, Christian, et al.
Publicado: (2013)

Huntington Disease: The Complexities of Making and Disclosing a Clinical Diagnosis After Premanifest Genetic Testing
por: McCusker, Elizabeth A., et al.
Publicado: (2017)

Intact sensory-motor network structure and function in far from onset premanifest Huntington’s disease
por: Gorges, Martin, et al.
Publicado: (2017)

The Pathophysiology and Pharmacological Treatment of Huntington Disease
por: Pidgeon, Connie, et al.
Publicado: (2013)

Perceptions about Research Participation among Individuals at Risk and Individuals with Premanifest Huntington’s Disease: A Survey Conducted by the European Huntington Association
por: Júlio, Filipa, et al.
Publicado: (2021)

Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease
por: Bartlett, Danielle M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jtol9hsuoq3f911lokjd6v62nl