HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury

Histone/protein deacetylases (HDAC) 1 and 2 are typically viewed as structurally and functionally similar enzymes present within various co-regulatory complexes. We tested differential effects of these isoforms in renal ischemia reperfusion injury (IRI) using inducible knockout mice and found no sig...

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Detalles Bibliográficos
Autores principales: Aufhauser, David D., Hernandez, Paul, Concors, Seth J., O’Brien, Ciaran, Wang, Zhonglin, Murken, Douglas R., Samanta, Arabinda, Beier, Ulf H., Krumeich, Lauren, Bhatti, Tricia R., Wang, Yanfeng, Ge, Guanghui, Wang, Liqing, Cheraghlou, Shayan, Wagner, Florence F., Holson, Edward B., Kalin, Jay H., Cole, Philip A., Hancock, Wayne W., Levine, Matthew H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079686/
https://www.ncbi.nlm.nih.gov/pubmed/33907245
http://dx.doi.org/10.1038/s41598-021-88242-3

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