Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A

Werner syndrome (WRN) is a rare progressive genetic disorder, caused by functional defects in WRN protein and RecQ4L DNA helicase. Acceleration of the aging process is initiated at puberty and the expected life span is approximately the late 50 s. However, a Wrn-deficient mouse model does not show p...

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Detalles Bibliográficos
Autores principales: Kang, So-mi, Yoon, Min-Ho, Lee, Su-Jin, Ahn, Jinsook, Yi, Sang Ah, Nam, Ki Hong, Park, Soyoung, Woo, Tae-Gyun, Cho, Jung-Hyun, Lee, Jaecheol, Ha, Nam-Chul, Park, Bum-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079706/
https://www.ncbi.nlm.nih.gov/pubmed/33907225
http://dx.doi.org/10.1038/s41598-021-88325-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079706/
https://www.ncbi.nlm.nih.gov/pubmed/33907225
http://dx.doi.org/10.1038/s41598-021-88325-1

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