Cargando…

Phospho-Site Mutations in Transcription Factor Suppressor of Hairless Impact Notch Signaling Activity During Hematopoiesis in Drosophila

The highly conserved Notch signaling pathway controls a multitude of developmental processes including hematopoiesis. Here, we provide evidence for a novel mechanism of tissue-specific Notch regulation involving phosphorylation of CSL transcription factors within the DNA-binding domain. Earlier we f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frankenreiter, Lisa, Gahr, Bernd M., Schmid, Hannes, Zimmermann, Mirjam, Deichsel, Sebastian, Hoffmeister, Philipp, Turkiewicz, Aleksandra, Borggrefe, Tilman, Oswald, Franz, Nagel, Anja C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079769/ https://www.ncbi.nlm.nih.gov/pubmed/33937259 http://dx.doi.org/10.3389/fcell.2021.658820

Ejemplares similares

Setting the Stage for Notch: The Drosophila Su(H)-Hairless Repressor Complex
por: Borggrefe, Tilman, et al.
Publicado: (2016)

Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless
por: Praxenthaler, Heiko, et al.
Publicado: (2017)

Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation
por: Pan, Leiling, et al.
Publicado: (2021)

Molecular Analysis of the Notch Repressor-Complex in Drosophila: Characterization of Potential Hairless Binding Sites on Suppressor of Hairless
por: Kurth, Patricia, et al.
Publicado: (2011)

Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics
por: Ferrante, Francesca, et al.
Publicado: (2022)

Dynamic chromatin regulation at Notch target genes
por: Giaimo, Benedetto Daniele, et al.
Publicado: (2016)

Phosphorylation of Suppressor of Hairless impedes its DNA-binding activity
por: Nagel, Anja C., et al.
Publicado: (2017)

Complex genetic interactions of novel Suppressor of Hairless alleles deficient in co-repressor binding
por: Preiss, Anette, et al.
Publicado: (2018)

A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes
por: Oswald, Franz, et al.
Publicado: (2016)

Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity
por: Maier, Dieter
Publicado: (2020)

Generation of New Hairless Alleles by Genomic Engineering at the Hairless Locus in Drosophila melanogaster
por: Praxenthaler, Heiko, et al.
Publicado: (2015)

Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway
por: Miller, Steven W, et al.
Publicado: (2019)

An RBPJ-Drosophila Model Reveals Dependence of RBPJ Protein Stability on the Formation of Transcription–Regulator Complexes
por: Gahr, Bernd M., et al.
Publicado: (2019)

Vascular Notch Signaling in Stress Hematopoiesis
por: Huang, Can, et al.
Publicado: (2021)

HDAC3 functions as a positive regulator in Notch signal transduction
por: Ferrante, Francesca, et al.
Publicado: (2020)

Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor
por: Kuang, Yi, et al.
Publicado: (2021)

The Membrane-Bound Notch Regulator Mnr Supports Notch Cleavage and Signaling Activity in Drosophila melanogaster
por: Nagel, Anja C., et al.
Publicado: (2021)

A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects
por: Gagliani, Ellen K., et al.
Publicado: (2022)

Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response
por: Giaimo, Benedetto Daniele, et al.
Publicado: (2018)

The tiny Hairless protein from Apis mellifera: a potent antagonist of Notch signaling in Drosophila melanogaster
por: Maier, Dieter, et al.
Publicado: (2008)

Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster
por: Yuan, Zhenyu, et al.
Publicado: (2016)

Gain of Function Notch Phenotypes Associated with Ectopic Expression of the Su(H) C-Terminal Domain Illustrate Separability of Notch and Hairless-Mediated Activities
por: Maier, Dieter, et al.
Publicado: (2013)

Genetic and Molecular Interactions between H(ΔCT), a Novel Allele of the Notch Antagonist Hairless, and the Histone Chaperone Asf1 in Drosophila melanogaster
por: Maier, Dieter, et al.
Publicado: (2023)

Identification of Novel Targets of CSL-Dependent Notch Signaling in Hematopoiesis
por: Hamidi, Habib, et al.
Publicado: (2011)

Drosophila Cyclin G Is a Regulator of the Notch Signalling Pathway during Wing Development
por: Nagel, Anja C., et al.
Publicado: (2016)

Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site
por: Yuan, Zhenyu, et al.
Publicado: (2019)

The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3
por: Hall, Daniel, et al.
Publicado: (2022)

Synergistic regulation of Notch signaling by different O-glycans promotes hematopoiesis
por: Tanwar, Ankit, et al.
Publicado: (2023)

NKL-Code in Normal and Aberrant Hematopoiesis
por: Nagel, Stefan
Publicado: (2021)

Notes on the Dentition of the Mexican Hairless Dogs
por: Waugh, James A.
Publicado: (1890)

Chromatin Regulator SPEN/SHARP in X Inactivation and Disease
por: Giaimo, Benedetto Daniele, et al.
Publicado: (2021)

SUMOylated non-canonical polycomb PRC1.6 complex as a prerequisite for recruitment of transcription factor RBPJ
por: Sotomska, Małgorzata, et al.
Publicado: (2021)

A single copy of large tumor suppressor 1 or large tumor suppressor 2 is sufficient for normal hematopoiesis
por: Li, Zhi-Gang, et al.
Publicado: (2020)

The bald and the beautiful: hairlessness in domestic dog breeds
por: Parker, Heidi G., et al.
Publicado: (2017)

Simple generation of hairless mice for in vivo imaging
por: Hoshino, Yoshikazu, et al.
Publicado: (2017)

Cutaneous transcriptome analysis in NIH hairless mice
por: Ji, Zhong-Hao, et al.
Publicado: (2017)

Hairless Hyperhidrotic Plaque in a Young Male
por: Kaushik, Akanksha, et al.
Publicado: (2021)

Notch Regulation of Hematopoiesis, Endothelial Precursor Cells, and Blood Vessel Formation: Orchestrating the Vasculature
por: Caolo, Vincenza, et al.
Publicado: (2012)

Notch-dependent and -independent functions of transcription factor RBPJ
por: Friedrich, Tobias, et al.
Publicado: (2022)

Nucleo-cytoplasmic shuttling of murine RBPJ by Hairless protein matches that of Su(H) protein in the model system Drosophila melanogaster
por: Wolf, Dorina B., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_it8arb2gb60pi23u0o5p3ie1ns