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Stem Cell-Based Therapy for Experimental Ischemic Stroke: A Preclinical Systematic Review
Stem cell transplantation offers promise in the treatment of ischemic stroke. Here we utilized systematic review, meta-analysis, and meta-regression to study the biological effect of stem cell treatments in animal models of ischemic stroke. A total of 98 eligible publications were included by search...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079818/ https://www.ncbi.nlm.nih.gov/pubmed/33935650 http://dx.doi.org/10.3389/fncel.2021.628908 |
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author | Zhang, Xi-Le Zhang, Xiao-Guang Huang, Yan-Ran Zheng, Yan-Yan Ying, Peng-Jie Zhang, Xiao-Jie Lu, Xiao Wang, Yi-Jing Zheng, Guo-Qing |
author_facet | Zhang, Xi-Le Zhang, Xiao-Guang Huang, Yan-Ran Zheng, Yan-Yan Ying, Peng-Jie Zhang, Xiao-Jie Lu, Xiao Wang, Yi-Jing Zheng, Guo-Qing |
author_sort | Zhang, Xi-Le |
collection | PubMed |
description | Stem cell transplantation offers promise in the treatment of ischemic stroke. Here we utilized systematic review, meta-analysis, and meta-regression to study the biological effect of stem cell treatments in animal models of ischemic stroke. A total of 98 eligible publications were included by searching PubMed, EMBASE, and Web of Science from inception to August 1, 2020. There are about 141 comparisons, involving 5,200 animals, that examined the effect of stem cell transplantation on neurological function and infarct volume as primary outcome measures in animal models for stroke. Stem cell-based therapy can improve both neurological function (effect size, −3.37; 95% confidence interval, −3.83 to −2.90) and infarct volume (effect size, −11.37; 95% confidence interval, −12.89 to −9.85) compared with controls. These results suggest that stem cell therapy could improve neurological function deficits and infarct volume, exerting potential neuroprotective effect for experimental ischemic stroke, but further clinical studies are still needed. |
format | Online Article Text |
id | pubmed-8079818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80798182021-04-29 Stem Cell-Based Therapy for Experimental Ischemic Stroke: A Preclinical Systematic Review Zhang, Xi-Le Zhang, Xiao-Guang Huang, Yan-Ran Zheng, Yan-Yan Ying, Peng-Jie Zhang, Xiao-Jie Lu, Xiao Wang, Yi-Jing Zheng, Guo-Qing Front Cell Neurosci Neuroscience Stem cell transplantation offers promise in the treatment of ischemic stroke. Here we utilized systematic review, meta-analysis, and meta-regression to study the biological effect of stem cell treatments in animal models of ischemic stroke. A total of 98 eligible publications were included by searching PubMed, EMBASE, and Web of Science from inception to August 1, 2020. There are about 141 comparisons, involving 5,200 animals, that examined the effect of stem cell transplantation on neurological function and infarct volume as primary outcome measures in animal models for stroke. Stem cell-based therapy can improve both neurological function (effect size, −3.37; 95% confidence interval, −3.83 to −2.90) and infarct volume (effect size, −11.37; 95% confidence interval, −12.89 to −9.85) compared with controls. These results suggest that stem cell therapy could improve neurological function deficits and infarct volume, exerting potential neuroprotective effect for experimental ischemic stroke, but further clinical studies are still needed. Frontiers Media S.A. 2021-04-14 /pmc/articles/PMC8079818/ /pubmed/33935650 http://dx.doi.org/10.3389/fncel.2021.628908 Text en Copyright © 2021 Zhang, Zhang, Huang, Zheng, Ying, Zhang, Lu, Wang and Zheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhang, Xi-Le Zhang, Xiao-Guang Huang, Yan-Ran Zheng, Yan-Yan Ying, Peng-Jie Zhang, Xiao-Jie Lu, Xiao Wang, Yi-Jing Zheng, Guo-Qing Stem Cell-Based Therapy for Experimental Ischemic Stroke: A Preclinical Systematic Review |
title | Stem Cell-Based Therapy for Experimental Ischemic Stroke: A Preclinical Systematic Review |
title_full | Stem Cell-Based Therapy for Experimental Ischemic Stroke: A Preclinical Systematic Review |
title_fullStr | Stem Cell-Based Therapy for Experimental Ischemic Stroke: A Preclinical Systematic Review |
title_full_unstemmed | Stem Cell-Based Therapy for Experimental Ischemic Stroke: A Preclinical Systematic Review |
title_short | Stem Cell-Based Therapy for Experimental Ischemic Stroke: A Preclinical Systematic Review |
title_sort | stem cell-based therapy for experimental ischemic stroke: a preclinical systematic review |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079818/ https://www.ncbi.nlm.nih.gov/pubmed/33935650 http://dx.doi.org/10.3389/fncel.2021.628908 |
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