Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis

Bone marrow necrosis (BMN) is a rare but important complication of hematological malignancies. We report the case of a 52-year-old male patient with a recurrence of acute lymphoblastic leukemia (ALL) accompanied by BMN. After re-induction therapy, bone marrow aspiration (BMA) and biopsy from the ili...

Descripción completa

Detalles Bibliográficos
Autores principales: Harada, Naonori, Nishimoto, Mitsutaka, Ikemoto, Aya, Okamura, Hiroshi, Koh, Shiro, Nanno, Satoru, Nakashima, Yasuhiro, Koh, Hideo, Nakane, Takahiko, Kuwae, Yuko, Ohsawa, Masahiko, Hino, Masayuki, Nakamae, Hirohisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079900/
https://www.ncbi.nlm.nih.gov/pubmed/33116012
http://dx.doi.org/10.2169/internalmedicine.5815-20
_version_ 1783685314496167936
author Harada, Naonori
Nishimoto, Mitsutaka
Ikemoto, Aya
Okamura, Hiroshi
Koh, Shiro
Nanno, Satoru
Nakashima, Yasuhiro
Koh, Hideo
Nakane, Takahiko
Kuwae, Yuko
Ohsawa, Masahiko
Hino, Masayuki
Nakamae, Hirohisa
author_facet Harada, Naonori
Nishimoto, Mitsutaka
Ikemoto, Aya
Okamura, Hiroshi
Koh, Shiro
Nanno, Satoru
Nakashima, Yasuhiro
Koh, Hideo
Nakane, Takahiko
Kuwae, Yuko
Ohsawa, Masahiko
Hino, Masayuki
Nakamae, Hirohisa
author_sort Harada, Naonori
collection PubMed
description Bone marrow necrosis (BMN) is a rare but important complication of hematological malignancies. We report the case of a 52-year-old male patient with a recurrence of acute lymphoblastic leukemia (ALL) accompanied by BMN. After re-induction therapy, bone marrow aspiration (BMA) and biopsy from the iliac bone showed necrotic cells and eosinophilic debris, respectively. Magnetic resonance imaging (MRI) showed heterogeneous signals in the bilateral iliac bone, possibly reflecting various stages of BMN. BMA from the sternum eventually revealed the recurrence of ALL after a few weeks. Comprehensive assessments, including MRI and repeated bone marrow tests, are required when evaluating the underlying hematological malignancies of patients with BMN.
format Online
Article
Text
id pubmed-8079900
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-80799002021-05-11 Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis Harada, Naonori Nishimoto, Mitsutaka Ikemoto, Aya Okamura, Hiroshi Koh, Shiro Nanno, Satoru Nakashima, Yasuhiro Koh, Hideo Nakane, Takahiko Kuwae, Yuko Ohsawa, Masahiko Hino, Masayuki Nakamae, Hirohisa Intern Med Case Report Bone marrow necrosis (BMN) is a rare but important complication of hematological malignancies. We report the case of a 52-year-old male patient with a recurrence of acute lymphoblastic leukemia (ALL) accompanied by BMN. After re-induction therapy, bone marrow aspiration (BMA) and biopsy from the iliac bone showed necrotic cells and eosinophilic debris, respectively. Magnetic resonance imaging (MRI) showed heterogeneous signals in the bilateral iliac bone, possibly reflecting various stages of BMN. BMA from the sternum eventually revealed the recurrence of ALL after a few weeks. Comprehensive assessments, including MRI and repeated bone marrow tests, are required when evaluating the underlying hematological malignancies of patients with BMN. The Japanese Society of Internal Medicine 2020-10-28 2021-04-01 /pmc/articles/PMC8079900/ /pubmed/33116012 http://dx.doi.org/10.2169/internalmedicine.5815-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Harada, Naonori
Nishimoto, Mitsutaka
Ikemoto, Aya
Okamura, Hiroshi
Koh, Shiro
Nanno, Satoru
Nakashima, Yasuhiro
Koh, Hideo
Nakane, Takahiko
Kuwae, Yuko
Ohsawa, Masahiko
Hino, Masayuki
Nakamae, Hirohisa
Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis
title Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis
title_full Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis
title_fullStr Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis
title_full_unstemmed Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis
title_short Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis
title_sort recurrence of acute lymphoblastic leukemia with bone marrow necrosis: a case report and review of the literature on the mri features of bone marrow necrosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079900/
https://www.ncbi.nlm.nih.gov/pubmed/33116012
http://dx.doi.org/10.2169/internalmedicine.5815-20
work_keys_str_mv AT haradanaonori recurrenceofacutelymphoblasticleukemiawithbonemarrownecrosisacasereportandreviewoftheliteratureonthemrifeaturesofbonemarrownecrosis
AT nishimotomitsutaka recurrenceofacutelymphoblasticleukemiawithbonemarrownecrosisacasereportandreviewoftheliteratureonthemrifeaturesofbonemarrownecrosis
AT ikemotoaya recurrenceofacutelymphoblasticleukemiawithbonemarrownecrosisacasereportandreviewoftheliteratureonthemrifeaturesofbonemarrownecrosis
AT okamurahiroshi recurrenceofacutelymphoblasticleukemiawithbonemarrownecrosisacasereportandreviewoftheliteratureonthemrifeaturesofbonemarrownecrosis
AT kohshiro recurrenceofacutelymphoblasticleukemiawithbonemarrownecrosisacasereportandreviewoftheliteratureonthemrifeaturesofbonemarrownecrosis
AT nannosatoru recurrenceofacutelymphoblasticleukemiawithbonemarrownecrosisacasereportandreviewoftheliteratureonthemrifeaturesofbonemarrownecrosis
AT nakashimayasuhiro recurrenceofacutelymphoblasticleukemiawithbonemarrownecrosisacasereportandreviewoftheliteratureonthemrifeaturesofbonemarrownecrosis
AT kohhideo recurrenceofacutelymphoblasticleukemiawithbonemarrownecrosisacasereportandreviewoftheliteratureonthemrifeaturesofbonemarrownecrosis
AT nakanetakahiko recurrenceofacutelymphoblasticleukemiawithbonemarrownecrosisacasereportandreviewoftheliteratureonthemrifeaturesofbonemarrownecrosis
AT kuwaeyuko recurrenceofacutelymphoblasticleukemiawithbonemarrownecrosisacasereportandreviewoftheliteratureonthemrifeaturesofbonemarrownecrosis
AT ohsawamasahiko recurrenceofacutelymphoblasticleukemiawithbonemarrownecrosisacasereportandreviewoftheliteratureonthemrifeaturesofbonemarrownecrosis
AT hinomasayuki recurrenceofacutelymphoblasticleukemiawithbonemarrownecrosisacasereportandreviewoftheliteratureonthemrifeaturesofbonemarrownecrosis
AT nakamaehirohisa recurrenceofacutelymphoblasticleukemiawithbonemarrownecrosisacasereportandreviewoftheliteratureonthemrifeaturesofbonemarrownecrosis

Ejemplares similares