Dehydrocostus Lactone Attenuates the Senescence of Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration via Inhibition of STING-TBK1/NF-κB and MAPK Signaling

The progression of intervertebral disc degeneration (IDD) is multifactorial with the senescence of nucleus pulposus (NP) cells and closely related to inflammation in NP cells. Dehydrocostus lactone (DHE) is a natural sesquiterpene lactone isolated from medicinal plants that has anti-inflammatory pro...

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Detalles Bibliográficos
Autores principales: Chen, Zhiqian, Yang, Xiao, Zhou, Yifan, Liang, Zhihao, Chen, Chen, Han, Chen, Cao, Xiankun, He, Wenxin, Zhang, Kai, Qin, An, Zhou, Tangjun, Zhao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079987/
https://www.ncbi.nlm.nih.gov/pubmed/33935734
http://dx.doi.org/10.3389/fphar.2021.641098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079987/
https://www.ncbi.nlm.nih.gov/pubmed/33935734
http://dx.doi.org/10.3389/fphar.2021.641098

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