Cargando…

Dehydrocostus Lactone Attenuates the Senescence of Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration via Inhibition of STING-TBK1/NF-κB and MAPK Signaling

The progression of intervertebral disc degeneration (IDD) is multifactorial with the senescence of nucleus pulposus (NP) cells and closely related to inflammation in NP cells. Dehydrocostus lactone (DHE) is a natural sesquiterpene lactone isolated from medicinal plants that has anti-inflammatory pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Zhiqian, Yang, Xiao, Zhou, Yifan, Liang, Zhihao, Chen, Chen, Han, Chen, Cao, Xiankun, He, Wenxin, Zhang, Kai, Qin, An, Zhou, Tangjun, Zhao, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079987/ https://www.ncbi.nlm.nih.gov/pubmed/33935734 http://dx.doi.org/10.3389/fphar.2021.641098

Ejemplares similares

Autologous fibroblasts induce fibrosis of the nucleus pulposus to maintain the stability of degenerative intervertebral discs
por: Chen, Chen, et al.
Publicado: (2020)

Specific PFKFB3 Inhibitor Memorably Ameliorates Intervertebral Disc Degeneration via Inhibiting NF-κB and MAPK Signaling Pathway and Reprogramming of Energy Metabolism of Nucleus Pulposus Cells
por: Cao, Xiankun, et al.
Publicado: (2022)

Prussian Blue Nanoparticles Stabilize SOD1 from Ubiquitination‐Proteasome Degradation to Rescue Intervertebral Disc Degeneration
por: Zhou, Tangjun, et al.
Publicado: (2022)

The Possible Anti-Inflammatory Effect of Dehydrocostus Lactone on DSS-Induced Colitis in Mice
por: Zhou, Qing, et al.
Publicado: (2020)

Engeletin Alleviates the Inflammation and Apoptosis in Intervertebral Disc Degeneration via Inhibiting the NF-κB and MAPK Pathways
por: Li, Baixing, et al.
Publicado: (2022)

Dehydrocostus lactone inhibits Candida albicans growth and biofilm formation
por: Zhang, Jingxiao, et al.
Publicado: (2023)

Senescence of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs
por: Kim, Ki-Won, et al.
Publicado: (2008)

Amelioration of Benign Prostatic Hyperplasia by Costunolide and Dehydrocostus Lactone in Wistar Rats
por: Choi, Dohyun, et al.
Publicado: (2021)

Dynamics of germination stimulants dehydrocostus lactone and costunolide in the root exudates and extracts of sunflower
por: Wu, Wenlong, et al.
Publicado: (2022)

PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling
por: Lin, Yongfang, et al.
Publicado: (2023)

Changes in the Molecular Phenotype of Nucleus Pulposus Cells with Intervertebral Disc Aging
por: Tang, Xinyan, et al.
Publicado: (2012)

Bleomycin induces fibrotic transformation of bone marrow stromal cells to treat height loss of intervertebral disc through the TGFβR1/Smad2/3 pathway
por: Yang, Xiao, et al.
Publicado: (2021)

Proteomic Signature of Nucleus Pulposus in Fetal Intervertebral Disc
por: Rajasekaran, Shanmuganathan, et al.
Publicado: (2020)

Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration
por: Li, Zheng, et al.
Publicado: (2019)

Endoscopic removal of nucleus pulposus of intervertebral disc on lumbar intervertebral disc protrusion and the influence on inflammatory factors and immune function
por: Xu, Gang, et al.
Publicado: (2020)

A novel COL2A1 mutation causing spondyloepiphyseal dysplasia congenita in a Chinese family
por: Zhou, Tangjun, et al.
Publicado: (2021)

Upregulated lnc-HRK-2:1 prompts nucleus pulposus cell senescence in intervertebral disc degeneration
por: Liang, Dongbo, et al.
Publicado: (2020)

Expression of ANGPTL4 in Nucleus Pulposus Tissues Is Associated with Intervertebral Disc Degeneration
por: Liu, Fan-jie, et al.
Publicado: (2021)

Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells
por: Xie, Chenglong, et al.
Publicado: (2022)

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration
por: Chen, Hai-Wei, et al.
Publicado: (2021)

PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells
por: Zhang, Zhenlei, et al.
Publicado: (2022)

The therapeutic effect of TBK1 in intervertebral disc degeneration via coordinating selective autophagy and autophagic functions
por: Hu, Sunli, et al.
Publicado: (2020)

Differential expression of p38 MAPK α, β, γ, δ isoforms in nucleus pulposus modulates macrophage polarization in intervertebral disc degeneration
por: Yang, Chen, et al.
Publicado: (2016)

Psoralen synergizes with exosome-loaded SPC25 to alleviate senescence of nucleus pulposus cells in intervertebral disc degeneration
por: Yang, Lei, et al.
Publicado: (2023)

Integrated transcriptome and proteome analyses identify novel regulatory network of nucleus pulposus cells in intervertebral disc degeneration
por: Xu, Chen, et al.
Publicado: (2021)

Dehydrocostus Lactone Attenuates Methicillin-Resistant Staphylococcus aureus-Induced Inflammation and Acute Lung Injury via Modulating Macrophage Polarization
por: Wu, Ya-Xian, et al.
Publicado: (2021)

Dehydrocostus Lactone Enhances Chemotherapeutic Potential of Doxorubicin in Lung Cancer by Inducing Cell Death and Limiting Metastasis
por: Sheng, Wei, et al.
Publicado: (2018)

Evaluation of Anti-Colitis Effect of KM1608 and Biodistribution of Dehydrocostus Lactone in Mice Using Bioimaging Analysis
por: Lee, Sullim, et al.
Publicado: (2020)

Antibacterial Activities of Echinops kebericho Mesfin Tuber Extracts and Isolation of the Most Active Compound, Dehydrocostus Lactone
por: Deyno, Serawit, et al.
Publicado: (2021)

CGRP Regulates Nucleus Pulposus Cell Apoptosis and Inflammation via the MAPK/NF-κB Signaling Pathways during Intervertebral Disc Degeneration
por: Sun, Kaiqiang, et al.
Publicado: (2021)

Eupatilin attenuates the senescence of nucleus pulposus cells and mitigates intervertebral disc degeneration via inhibition of the MAPK/NF-κB signaling pathway
por: Yang, Huan, et al.
Publicado: (2022)

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
por: Sakai, Daisuke, et al.
Publicado: (2012)

Characterisation of porous knitted titanium for replacement of intervertebral disc nucleus pulposus
por: Tendulkar, Gauri, et al.
Publicado: (2017)

Dimethyl fumarate protects nucleus pulposus cells from inflammation and oxidative stress and delays the intervertebral disc degeneration
por: Zhu, Hainian, et al.
Publicado: (2020)

Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats
por: Wang, Jianle, et al.
Publicado: (2018)

TMT-Based Proteomics Analysis of Senescent Nucleus Pulposus from Patients with Intervertebral Disc Degeneration
por: Zhang, Guangzhi, et al.
Publicado: (2023)

Transplantation of active nucleus pulposus cells with a keep-charging hydrogel microsphere system to rescue intervertebral disc degeneration
por: Tang, Yingchuang, et al.
Publicado: (2023)

Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc
por: Chen, Sheng, et al.
Publicado: (2022)

Dehydrocostus lactone attenuates osteoclastogenesis and osteoclast‐induced bone loss by modulating NF‐κB signalling pathway
por: Hu, Bin, et al.
Publicado: (2019)

Dehydrocostus lactone inhibits NFATc1 via regulation of IKK, JNK, and Nrf2, thereby attenuating osteoclastogenesis
por: Lee, Hye In, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_boumjplslquk7e3cqrnb5288e4