Cargando…

IR-61 Improves Voiding Function via Mitochondrial Protection in Diabetic Rats

Diabetic bladder dysfunction (DBD) afflicts nearly half of diabetic patients, but effective treatment is lacking. In this study, IR-61, a novel heptamethine cyanine dye with potential antioxidant effects, was investigated to determine whether it can alleviate DBD. Rats were intraperitoneally injecte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jianwu, Dai, Linyong, Yue, Xiaofeng, Shen, Chongxing, Li, Tong, Long, Lei, Zhi, Yi, Wang, Yawei, Shen, Gufang, Shi, Chunmeng, Liu, Yunsheng, Fang, Qiang, Li, Weibing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080033/ https://www.ncbi.nlm.nih.gov/pubmed/33935703 http://dx.doi.org/10.3389/fphar.2021.608637

Ejemplares similares

Nocturnal oxygen therapy as an option for early COVID-19
por: Shen, Chongxing, et al.
Publicado: (2020)

Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway
por: Li, Xueru, et al.
Publicado: (2020)

The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes modelvia mitochondrial protection
por: Yue, Xiao-Feng, et al.
Publicado: (2021)

The TβR II-targeted aptamer S58 prevents fibrosis after glaucoma filtration surgery
por: Li, Xueru, et al.
Publicado: (2020)

ID1/ID3 mediate the contribution of skin fibroblasts to local nerve regeneration through Itga6 in wound repair
por: Chen, Zelin, et al.
Publicado: (2021)

Development and Evaluation of Novel Metformin Derivative Metformin Threonate for Brain Ischemia Treatment
por: Zhang, Gufang, et al.
Publicado: (2022)

Fibrogenic fibroblast-selective near-infrared phototherapy to control scarring
por: Chen, Zelin, et al.
Publicado: (2019)

MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases
por: Zhang, Guang-Qiong, et al.
Publicado: (2021)

Metabolic reprogramming induced by DCA enhances cisplatin sensitivity through increasing mitochondrial oxidative stress in cholangiocarcinoma
por: Qin, Hanjiao, et al.
Publicado: (2023)

RU486 Metabolite Inhibits CCN1/Cyr61 Secretion by MDA-MB-231-Endothelial Adhesion
por: Yu, Suhong, et al.
Publicado: (2019)

Adenosine monophosphate activated protein kinase contributes to skeletal muscle health through the control of mitochondrial function
por: Yan, Yan, et al.
Publicado: (2022)

Sea Buckthorn Proanthocyanidins are the Protective Agent of Mitochondrial Function in Macrophages Under Oxidative Stress
por: Liu, Keshan, et al.
Publicado: (2022)

Mitochondrial Targeting Therapeutics: Promising Role of Natural Products in Non-alcoholic Fatty Liver Disease
por: Xu, Jingqi, et al.
Publicado: (2021)

Severe cutaneous adverse reactions to drugs: A real-world pharmacovigilance study using the FDA Adverse Event Reporting System database
por: Li, Dongxuan, et al.
Publicado: (2023)

Inhibition of Autophagy Prevents Panax Notoginseng Saponins (PNS) Protection on Cardiac Myocytes Against Endoplasmic Reticulum (ER) Stress-Induced Mitochondrial Injury, Ca(2+) Homeostasis and Associated Apoptosis
por: Chen, Jun, et al.
Publicado: (2021)

Edgeworthia gardneri (Wall.) Meisn. Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3β/FoxO1 Signaling Pathway in Human HepG2 Hepatocytes
por: Zhang, Yi, et al.
Publicado: (2020)

The Void
por: Close, Frank
Publicado: (2007)

Astragaloside II Ameliorated Podocyte Injury and Mitochondrial Dysfunction in Streptozotocin-Induced Diabetic Rats
por: Su, Jun, et al.
Publicado: (2021)

Pioglitazone Inhibits Diabetes-Induced Atrial Mitochondrial Oxidative Stress and Improves Mitochondrial Biogenesis, Dynamics, and Function Through the PPAR-γ/PGC-1α Signaling Pathway
por: Zhang, Zhiwei, et al.
Publicado: (2021)

Tongluo Yishen Decoction Ameliorates Renal Fibrosis via Regulating Mitochondrial Dysfunction Induced by Oxidative Stress in Unilateral Ureteral Obstruction Rats
por: Jia, Qi, et al.
Publicado: (2021)

Current Diagnosis and Management of Immune Related Adverse Events (irAEs) Induced by Immune Checkpoint Inhibitor Therapy
por: Kumar, Vivek, et al.
Publicado: (2017)

Retroperitoneal dedifferentiated liposarcoma: Analysis of 61 cases from a large institution
por: Luo, Peng, et al.
Publicado: (2018)

Preclinical reserpine models recapitulating motor and non-motor features of Parkinson’s disease: Roles of epigenetic upregulation of alpha-synuclein and autophagy impairment
por: Li, Yang, et al.
Publicado: (2022)

Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells
por: Li, Tonghui, et al.
Publicado: (2022)

Corrigendum: Current Diagnosis and Management of Immune Related Adverse Events (irAEs) Induced by Immune Checkpoint Inhibitor Therapy
por: Kumar, Vivek, et al.
Publicado: (2017)

Mitochondrial toxicity evaluation of traditional Chinese medicine injections with a dual in vitro approach
por: Shen, Yunfu, et al.
Publicado: (2022)

Melatonin Attenuates Sepsis-Induced Acute Lung Injury Through Improvement of Epithelial Sodium Channel-Mediated Alveolar Fluid Clearance Via Activation of SIRT1/SGK1/Nedd4-2 Signaling Pathway
por: Li, Jing, et al.
Publicado: (2020)

Effects of Intestinal FXR-Related Molecules on Intestinal Mucosal Barriers in Biliary Tract Obstruction
por: Yan, Meng, et al.
Publicado: (2022)

Deciphering the action mechanism of paeoniflorin in suppressing pancreatic cancer: A network pharmacology study and experimental validation
por: Cao, Chunhao, et al.
Publicado: (2022)

Radix Rehmanniae Praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer’s disease mice through modulation of INSR/IRS-1/AKT/GSK-3β signaling pathway and intestinal microbiota
por: Su, Yunfang, et al.
Publicado: (2023)

Application of FT-IR spectroscopy and chemometric technique for the identification of three different parts of Camellia nitidissima and discrimination of its authenticated product
por: Tew, Wan Yin, et al.
Publicado: (2022)

Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases
por: Fu, Tong-Tong, et al.
Publicado: (2022)

BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux
por: Shen, Shuangjun, et al.
Publicado: (2020)

Comparison of voiding vesicoureteral urosonography with fluoroscopic voiding cystourethrography in children with vesicoureteral reflux
por: Yang, Bin, et al.
Publicado: (2023)

Agriophyllum Oligosaccharides Ameliorate Diabetic Insulin Resistance Through INS-R/IRS/Glut4-Mediated Insulin Pathway in db/db Mice and MIN6 Cells
por: Bao, Shuyin, et al.
Publicado: (2021)

Paeoniflorin Ameliorates Skeletal Muscle Atrophy in Chronic Kidney Disease via AMPK/SIRT1/PGC-1α-Mediated Oxidative Stress and Mitochondrial Dysfunction
por: Li, Qiang, et al.
Publicado: (2022)

Voiding Dysfunction
Publicado: (2016)

The efficacy and safety of condoliase for lumbar disc herniation: a systematic review and meta-analysis
por: Huang, Zeling, et al.
Publicado: (2023)

Placenta Peptide Can Protect Mitochondrial Dysfunction through Inhibiting ROS and TNF-α Generation, by Maintaining Mitochondrial Dynamic Network and by Increasing IL-6 Level during Chronic Fatigue
por: Muluye, Rekik A., et al.
Publicado: (2016)

Impaired Insulin Signaling is Associated with Hepatic Mitochondrial Dysfunction in IR(+/−)-IRS-1(+/−) Double Heterozygous (IR-IRS1dh) Mice
por: Franko, Andras, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ncad6qclmaomidvrqanrut690n