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Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors

Contrast enhancement in optoacoustic (photoacoustic) imaging can be achieved with agents that exhibit high absorption cross-sections, high photostability, low quantum yield, low toxicity, and preferential bio-distribution and clearance profiles. Based on advantageous photophysical properties of croc...

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Autores principales: Liu, Nian, Gujrati, Vipul, Malekzadeh-Najafabadi, Jaber, Werner, Juan Pablo Fuenzalida, Klemm, Uwe, Tang, Longguang, Chen, Zhenyue, Prakash, Jaya, Huang, Yuanhui, Stiel, Andre, Mettenleiter, Gabriele, Aichler, Michaela, Blutke, Andreas, Walch, Axel, Kleigrewe, Karin, Razansky, Daniel, Sattler, Michael, Ntziachristos, Vasilis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080078/
https://www.ncbi.nlm.nih.gov/pubmed/33948433
http://dx.doi.org/10.1016/j.pacs.2021.100263
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author Liu, Nian
Gujrati, Vipul
Malekzadeh-Najafabadi, Jaber
Werner, Juan Pablo Fuenzalida
Klemm, Uwe
Tang, Longguang
Chen, Zhenyue
Prakash, Jaya
Huang, Yuanhui
Stiel, Andre
Mettenleiter, Gabriele
Aichler, Michaela
Blutke, Andreas
Walch, Axel
Kleigrewe, Karin
Razansky, Daniel
Sattler, Michael
Ntziachristos, Vasilis
author_facet Liu, Nian
Gujrati, Vipul
Malekzadeh-Najafabadi, Jaber
Werner, Juan Pablo Fuenzalida
Klemm, Uwe
Tang, Longguang
Chen, Zhenyue
Prakash, Jaya
Huang, Yuanhui
Stiel, Andre
Mettenleiter, Gabriele
Aichler, Michaela
Blutke, Andreas
Walch, Axel
Kleigrewe, Karin
Razansky, Daniel
Sattler, Michael
Ntziachristos, Vasilis
author_sort Liu, Nian
collection PubMed
description Contrast enhancement in optoacoustic (photoacoustic) imaging can be achieved with agents that exhibit high absorption cross-sections, high photostability, low quantum yield, low toxicity, and preferential bio-distribution and clearance profiles. Based on advantageous photophysical properties of croconaine dyes, we explored croconaine-based nanoparticles (CR780RGD-NPs) as highly efficient contrast agents for targeted optoacoustic imaging of challenging preclinical tumor targets. Initial characterization of the CR780 dye was followed by modifications using polyethylene glycol and the cancer-targeting c(RGDyC) peptide, resulting in self-assembled ultrasmall particles with long circulation time and active tumor targeting. Preferential bio-distribution was demonstrated in orthotopic mouse brain tumor models by multispectral optoacoustic tomography (MSOT) imaging and histological analysis. Our findings showcase particle accumulation in brain tumors with sustainable strong optoacoustic signals and minimal toxic side effects. This work points to CR780RGD-NPs as a promising optoacoustic contrast agent for potential use in the diagnosis and image-guided resection of brain tumors.
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spelling pubmed-80800782021-05-03 Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors Liu, Nian Gujrati, Vipul Malekzadeh-Najafabadi, Jaber Werner, Juan Pablo Fuenzalida Klemm, Uwe Tang, Longguang Chen, Zhenyue Prakash, Jaya Huang, Yuanhui Stiel, Andre Mettenleiter, Gabriele Aichler, Michaela Blutke, Andreas Walch, Axel Kleigrewe, Karin Razansky, Daniel Sattler, Michael Ntziachristos, Vasilis Photoacoustics Research Article Contrast enhancement in optoacoustic (photoacoustic) imaging can be achieved with agents that exhibit high absorption cross-sections, high photostability, low quantum yield, low toxicity, and preferential bio-distribution and clearance profiles. Based on advantageous photophysical properties of croconaine dyes, we explored croconaine-based nanoparticles (CR780RGD-NPs) as highly efficient contrast agents for targeted optoacoustic imaging of challenging preclinical tumor targets. Initial characterization of the CR780 dye was followed by modifications using polyethylene glycol and the cancer-targeting c(RGDyC) peptide, resulting in self-assembled ultrasmall particles with long circulation time and active tumor targeting. Preferential bio-distribution was demonstrated in orthotopic mouse brain tumor models by multispectral optoacoustic tomography (MSOT) imaging and histological analysis. Our findings showcase particle accumulation in brain tumors with sustainable strong optoacoustic signals and minimal toxic side effects. This work points to CR780RGD-NPs as a promising optoacoustic contrast agent for potential use in the diagnosis and image-guided resection of brain tumors. Elsevier 2021-03-23 /pmc/articles/PMC8080078/ /pubmed/33948433 http://dx.doi.org/10.1016/j.pacs.2021.100263 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Liu, Nian
Gujrati, Vipul
Malekzadeh-Najafabadi, Jaber
Werner, Juan Pablo Fuenzalida
Klemm, Uwe
Tang, Longguang
Chen, Zhenyue
Prakash, Jaya
Huang, Yuanhui
Stiel, Andre
Mettenleiter, Gabriele
Aichler, Michaela
Blutke, Andreas
Walch, Axel
Kleigrewe, Karin
Razansky, Daniel
Sattler, Michael
Ntziachristos, Vasilis
Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors
title Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors
title_full Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors
title_fullStr Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors
title_full_unstemmed Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors
title_short Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors
title_sort croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080078/
https://www.ncbi.nlm.nih.gov/pubmed/33948433
http://dx.doi.org/10.1016/j.pacs.2021.100263
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