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Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors
Contrast enhancement in optoacoustic (photoacoustic) imaging can be achieved with agents that exhibit high absorption cross-sections, high photostability, low quantum yield, low toxicity, and preferential bio-distribution and clearance profiles. Based on advantageous photophysical properties of croc...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080078/ https://www.ncbi.nlm.nih.gov/pubmed/33948433 http://dx.doi.org/10.1016/j.pacs.2021.100263 |
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author | Liu, Nian Gujrati, Vipul Malekzadeh-Najafabadi, Jaber Werner, Juan Pablo Fuenzalida Klemm, Uwe Tang, Longguang Chen, Zhenyue Prakash, Jaya Huang, Yuanhui Stiel, Andre Mettenleiter, Gabriele Aichler, Michaela Blutke, Andreas Walch, Axel Kleigrewe, Karin Razansky, Daniel Sattler, Michael Ntziachristos, Vasilis |
author_facet | Liu, Nian Gujrati, Vipul Malekzadeh-Najafabadi, Jaber Werner, Juan Pablo Fuenzalida Klemm, Uwe Tang, Longguang Chen, Zhenyue Prakash, Jaya Huang, Yuanhui Stiel, Andre Mettenleiter, Gabriele Aichler, Michaela Blutke, Andreas Walch, Axel Kleigrewe, Karin Razansky, Daniel Sattler, Michael Ntziachristos, Vasilis |
author_sort | Liu, Nian |
collection | PubMed |
description | Contrast enhancement in optoacoustic (photoacoustic) imaging can be achieved with agents that exhibit high absorption cross-sections, high photostability, low quantum yield, low toxicity, and preferential bio-distribution and clearance profiles. Based on advantageous photophysical properties of croconaine dyes, we explored croconaine-based nanoparticles (CR780RGD-NPs) as highly efficient contrast agents for targeted optoacoustic imaging of challenging preclinical tumor targets. Initial characterization of the CR780 dye was followed by modifications using polyethylene glycol and the cancer-targeting c(RGDyC) peptide, resulting in self-assembled ultrasmall particles with long circulation time and active tumor targeting. Preferential bio-distribution was demonstrated in orthotopic mouse brain tumor models by multispectral optoacoustic tomography (MSOT) imaging and histological analysis. Our findings showcase particle accumulation in brain tumors with sustainable strong optoacoustic signals and minimal toxic side effects. This work points to CR780RGD-NPs as a promising optoacoustic contrast agent for potential use in the diagnosis and image-guided resection of brain tumors. |
format | Online Article Text |
id | pubmed-8080078 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-80800782021-05-03 Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors Liu, Nian Gujrati, Vipul Malekzadeh-Najafabadi, Jaber Werner, Juan Pablo Fuenzalida Klemm, Uwe Tang, Longguang Chen, Zhenyue Prakash, Jaya Huang, Yuanhui Stiel, Andre Mettenleiter, Gabriele Aichler, Michaela Blutke, Andreas Walch, Axel Kleigrewe, Karin Razansky, Daniel Sattler, Michael Ntziachristos, Vasilis Photoacoustics Research Article Contrast enhancement in optoacoustic (photoacoustic) imaging can be achieved with agents that exhibit high absorption cross-sections, high photostability, low quantum yield, low toxicity, and preferential bio-distribution and clearance profiles. Based on advantageous photophysical properties of croconaine dyes, we explored croconaine-based nanoparticles (CR780RGD-NPs) as highly efficient contrast agents for targeted optoacoustic imaging of challenging preclinical tumor targets. Initial characterization of the CR780 dye was followed by modifications using polyethylene glycol and the cancer-targeting c(RGDyC) peptide, resulting in self-assembled ultrasmall particles with long circulation time and active tumor targeting. Preferential bio-distribution was demonstrated in orthotopic mouse brain tumor models by multispectral optoacoustic tomography (MSOT) imaging and histological analysis. Our findings showcase particle accumulation in brain tumors with sustainable strong optoacoustic signals and minimal toxic side effects. This work points to CR780RGD-NPs as a promising optoacoustic contrast agent for potential use in the diagnosis and image-guided resection of brain tumors. Elsevier 2021-03-23 /pmc/articles/PMC8080078/ /pubmed/33948433 http://dx.doi.org/10.1016/j.pacs.2021.100263 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Liu, Nian Gujrati, Vipul Malekzadeh-Najafabadi, Jaber Werner, Juan Pablo Fuenzalida Klemm, Uwe Tang, Longguang Chen, Zhenyue Prakash, Jaya Huang, Yuanhui Stiel, Andre Mettenleiter, Gabriele Aichler, Michaela Blutke, Andreas Walch, Axel Kleigrewe, Karin Razansky, Daniel Sattler, Michael Ntziachristos, Vasilis Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors |
title | Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors |
title_full | Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors |
title_fullStr | Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors |
title_full_unstemmed | Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors |
title_short | Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors |
title_sort | croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080078/ https://www.ncbi.nlm.nih.gov/pubmed/33948433 http://dx.doi.org/10.1016/j.pacs.2021.100263 |
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