Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?

On-target/off-tumor toxicity is one of the major concerns regarding CAR T-cell therapy. Kosti et al.(1) demonstrate that this form of toxicity can be prevented by designing a CAR whose expression is controlled by oxygen levels in the tumor environment.

Detalles Bibliográficos
Autores principales: Prinzing, Brooke, Krenciute, Giedre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Preview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080122/
https://www.ncbi.nlm.nih.gov/pubmed/33948575
http://dx.doi.org/10.1016/j.xcrm.2021.100244
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author Prinzing, Brooke
Krenciute, Giedre
author_facet Prinzing, Brooke
Krenciute, Giedre
author_sort Prinzing, Brooke
collection PubMed
description On-target/off-tumor toxicity is one of the major concerns regarding CAR T-cell therapy. Kosti et al.(1) demonstrate that this form of toxicity can be prevented by designing a CAR whose expression is controlled by oxygen levels in the tumor environment.
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spelling pubmed-80801222021-05-03 Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma? Prinzing, Brooke Krenciute, Giedre Cell Rep Med Preview On-target/off-tumor toxicity is one of the major concerns regarding CAR T-cell therapy. Kosti et al.(1) demonstrate that this form of toxicity can be prevented by designing a CAR whose expression is controlled by oxygen levels in the tumor environment. Elsevier 2021-04-20 /pmc/articles/PMC8080122/ /pubmed/33948575 http://dx.doi.org/10.1016/j.xcrm.2021.100244 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Prinzing, Brooke
Krenciute, Giedre
Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?
title Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?
title_full Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?
title_fullStr Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?
title_full_unstemmed Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?
title_short Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?
title_sort hypoxia-inducible car expression: an answer to the on-target/off-tumor dilemma?
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080122/
https://www.ncbi.nlm.nih.gov/pubmed/33948575
http://dx.doi.org/10.1016/j.xcrm.2021.100244
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AT krenciutegiedre hypoxiainduciblecarexpressionananswertotheontargetofftumordilemma

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