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Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?
On-target/off-tumor toxicity is one of the major concerns regarding CAR T-cell therapy. Kosti et al.(1) demonstrate that this form of toxicity can be prevented by designing a CAR whose expression is controlled by oxygen levels in the tumor environment.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080122/ https://www.ncbi.nlm.nih.gov/pubmed/33948575 http://dx.doi.org/10.1016/j.xcrm.2021.100244 |