Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities

Essential E3 ubiquitin ligase HUWE1 (HECT, UBA, and WWE domain containing 1) regulates key factors, such as p53. Although mutations in HUWE1 cause heterogenous neurodevelopmental X-linked intellectual disabilities (XLIDs), the disease mechanisms common to these syndromes remain unknown. In this work...

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Detalles Bibliográficos
Autores principales: Aprigliano, Rossana, Aksu, Merdane Ezgi, Bradamante, Stefano, Mihaljevic, Boris, Wang, Wei, Rian, Kristin, Montaldo, Nicola P., Grooms, Kayla Mae, Fordyce Martin, Sarah L., Bordin, Diana L., Bosshard, Matthias, Peng, Yunhui, Alexov, Emil, Skinner, Cindy, Liabakk, Nina-Beate, Sullivan, Gareth J., Bjørås, Magnar, Schwartz, Charles E., van Loon, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080178/
https://www.ncbi.nlm.nih.gov/pubmed/33948573
http://dx.doi.org/10.1016/j.xcrm.2021.100240

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