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Association of human papillomavirus genotype distribution and cervical cytology: a cross-sectional study

The present study attempted to analyse human papillomavirus (HPV) genotype distribution and its association with cervical cytology results in women in western China. The present retrospective analysis was performed in 1089 female outpatients with a positive HPV test result who had undergone a cervic...

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Autores principales: Liu, Fang, Chang, Li, Bai, Ting, Liu, Xiaojuan, Hu, Jinliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080181/
https://www.ncbi.nlm.nih.gov/pubmed/33843533
http://dx.doi.org/10.1017/S0950268821000741
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author Liu, Fang
Chang, Li
Bai, Ting
Liu, Xiaojuan
Hu, Jinliang
author_facet Liu, Fang
Chang, Li
Bai, Ting
Liu, Xiaojuan
Hu, Jinliang
author_sort Liu, Fang
collection PubMed
description The present study attempted to analyse human papillomavirus (HPV) genotype distribution and its association with cervical cytology results in women in western China. The present retrospective analysis was performed in 1089 female outpatients with a positive HPV test result who had undergone a cervical cytology test at the gynaecological clinic, West China Second Hospital, Sichuan University, China, between January 2014 and December 2016. Of the 1089 patients with HPV infection, multiple HPV genotypes were detected in 220 patients (20.20%). Among the 1368 HPV genotypes detected, 1145 (83.70%) were high-risk subtypes. The most common genotypes were HPV-52 (18.64%), HPV-16 (16.59%), HPV-58 (13.23%), HPV-18 (6.80%), HPV-56 (5.56%) and HPV-59 (5.56%). Cervical cytology revealed abnormal cells in 430 (39.49%) patients. The most common diagnoses were atypical squamous cells of undetermined significance (ASC-US; 236 cases, 54.88%), low-grade squamous intraepithelial lesions (LSIL; 151 cases, 35.12%), high-grade squamous intraepithelial lesions (HSIL; 63 cases, 14.65%) and atypical glandular cells (AGC; 21 cases, 4.88%). HPV-66 was significantly associated (P = 0.037) with ASC; HPV-52 and HPV-56 were significantly associated with LSIL (P = 0.009 and 0.026, respectively); HPV-16 (P < 0.001), HPV-33 (P = 0.014) and HPV-58 (P = 0.003) were significantly associated with HSIL; and HPV-16 (P = 0.005) was significantly associated with AGC. HPV-16, HPV-52 and HPV-58 are associated with different diagnoses in patients with positive cervical cytological findings.
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spelling pubmed-80801812021-05-13 Association of human papillomavirus genotype distribution and cervical cytology: a cross-sectional study Liu, Fang Chang, Li Bai, Ting Liu, Xiaojuan Hu, Jinliang Epidemiol Infect Original Paper The present study attempted to analyse human papillomavirus (HPV) genotype distribution and its association with cervical cytology results in women in western China. The present retrospective analysis was performed in 1089 female outpatients with a positive HPV test result who had undergone a cervical cytology test at the gynaecological clinic, West China Second Hospital, Sichuan University, China, between January 2014 and December 2016. Of the 1089 patients with HPV infection, multiple HPV genotypes were detected in 220 patients (20.20%). Among the 1368 HPV genotypes detected, 1145 (83.70%) were high-risk subtypes. The most common genotypes were HPV-52 (18.64%), HPV-16 (16.59%), HPV-58 (13.23%), HPV-18 (6.80%), HPV-56 (5.56%) and HPV-59 (5.56%). Cervical cytology revealed abnormal cells in 430 (39.49%) patients. The most common diagnoses were atypical squamous cells of undetermined significance (ASC-US; 236 cases, 54.88%), low-grade squamous intraepithelial lesions (LSIL; 151 cases, 35.12%), high-grade squamous intraepithelial lesions (HSIL; 63 cases, 14.65%) and atypical glandular cells (AGC; 21 cases, 4.88%). HPV-66 was significantly associated (P = 0.037) with ASC; HPV-52 and HPV-56 were significantly associated with LSIL (P = 0.009 and 0.026, respectively); HPV-16 (P < 0.001), HPV-33 (P = 0.014) and HPV-58 (P = 0.003) were significantly associated with HSIL; and HPV-16 (P = 0.005) was significantly associated with AGC. HPV-16, HPV-52 and HPV-58 are associated with different diagnoses in patients with positive cervical cytological findings. Cambridge University Press 2021-04-12 /pmc/articles/PMC8080181/ /pubmed/33843533 http://dx.doi.org/10.1017/S0950268821000741 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
spellingShingle Original Paper
Liu, Fang
Chang, Li
Bai, Ting
Liu, Xiaojuan
Hu, Jinliang
Association of human papillomavirus genotype distribution and cervical cytology: a cross-sectional study
title Association of human papillomavirus genotype distribution and cervical cytology: a cross-sectional study
title_full Association of human papillomavirus genotype distribution and cervical cytology: a cross-sectional study
title_fullStr Association of human papillomavirus genotype distribution and cervical cytology: a cross-sectional study
title_full_unstemmed Association of human papillomavirus genotype distribution and cervical cytology: a cross-sectional study
title_short Association of human papillomavirus genotype distribution and cervical cytology: a cross-sectional study
title_sort association of human papillomavirus genotype distribution and cervical cytology: a cross-sectional study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080181/
https://www.ncbi.nlm.nih.gov/pubmed/33843533
http://dx.doi.org/10.1017/S0950268821000741
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