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Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase (ECONASE (®) XT) produced by Trichoderma reesei CBS 140027 as a feed additive for piglets (weaned), pigs for fattening, chickens for fattening, chickens reared for laying, laying hens, turkeys for fattening, turkeys reared for breeding and minor poultry species (Roal Oy)

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of ECONASE (®) XT (endo‐1,4‐β‐xylanase) produced by a genetically modified strain of Trichoderma reesei (CBS 140027) as a zootechnical feed additive for piglets (weaned), pigs...

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Autores principales: Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Dusemund, Birgit, Fašmon Durjava, Mojca, Kouba, Maryline, López‐Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Cocconcelli, Pier Sandro, Glandorf, Boet, Gropp, Jűrgen, Prieto Maradona, Miguel, Rychen, Guido, Saarela, Maria, Anguita, Montserrat, Galobart, Jaume, Pettenati, Elisa, Tarrés‐Call, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080292/
https://www.ncbi.nlm.nih.gov/pubmed/33959202
http://dx.doi.org/10.2903/j.efsa.2021.6536
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author Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Fašmon Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Cocconcelli, Pier Sandro
Glandorf, Boet
Gropp, Jűrgen
Prieto Maradona, Miguel
Rychen, Guido
Saarela, Maria
Anguita, Montserrat
Galobart, Jaume
Pettenati, Elisa
Tarrés‐Call, Jordi
author_facet Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Fašmon Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Cocconcelli, Pier Sandro
Glandorf, Boet
Gropp, Jűrgen
Prieto Maradona, Miguel
Rychen, Guido
Saarela, Maria
Anguita, Montserrat
Galobart, Jaume
Pettenati, Elisa
Tarrés‐Call, Jordi
collection PubMed
description Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of ECONASE (®) XT (endo‐1,4‐β‐xylanase) produced by a genetically modified strain of Trichoderma reesei (CBS 140027) as a zootechnical feed additive for piglets (weaned), pigs for fattening, chickens for fattening, chickens reared for laying, laying hens, turkeys for fattening, turkeys reared for breeding and minor poultry species. The recipient strain and the production strain T. reesei CBS 140027 are considered safe. The additive is safe for chickens for fattening and weaned piglets at the maximum recommended doses (16,000 and 24,000 BXU/kg feed, respectively) with a wide margin of safety (100‐fold and 50‐fold, respectively). These conclusions are extended to chickens reared for laying and to pigs for fattening at 16,000 and 24,000 BXU/kg feed, respectively. The additive is safe for turkeys for fattening or reared for breeding at 16,000 BXU/kg feed. The FEEDAP Panel cannot conclude on the safety of the additive for laying hens and for minor poultry species for laying at the proposed conditions of use. The information provided does not allow to conclude on the safety of the use of ECONASE XT (®) P/L produced by T. reesei CBS 140027 in animal nutrition for the consumers. The use of the additive under assessment in animal nutrition does not raise safety concerns for the environment. ECONASE (®) XT L is non‐irritant to the skin or to the eyes. In absence of data, the FEEDAP Panel cannot conclude on the potential of the solid product to be irritant to skin and eyes and on the potential of the additive in all forms to be a dermal sensitiser. All forms of the additive should be considered as respiratory sensitisers. All forms of the additive are considered efficacious at the minimum recommended levels for the target species.
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spelling pubmed-80802922021-05-05 Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase (ECONASE (®) XT) produced by Trichoderma reesei CBS 140027 as a feed additive for piglets (weaned), pigs for fattening, chickens for fattening, chickens reared for laying, laying hens, turkeys for fattening, turkeys reared for breeding and minor poultry species (Roal Oy) Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Cocconcelli, Pier Sandro Glandorf, Boet Gropp, Jűrgen Prieto Maradona, Miguel Rychen, Guido Saarela, Maria Anguita, Montserrat Galobart, Jaume Pettenati, Elisa Tarrés‐Call, Jordi EFSA J Scientific Opinion Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of ECONASE (®) XT (endo‐1,4‐β‐xylanase) produced by a genetically modified strain of Trichoderma reesei (CBS 140027) as a zootechnical feed additive for piglets (weaned), pigs for fattening, chickens for fattening, chickens reared for laying, laying hens, turkeys for fattening, turkeys reared for breeding and minor poultry species. The recipient strain and the production strain T. reesei CBS 140027 are considered safe. The additive is safe for chickens for fattening and weaned piglets at the maximum recommended doses (16,000 and 24,000 BXU/kg feed, respectively) with a wide margin of safety (100‐fold and 50‐fold, respectively). These conclusions are extended to chickens reared for laying and to pigs for fattening at 16,000 and 24,000 BXU/kg feed, respectively. The additive is safe for turkeys for fattening or reared for breeding at 16,000 BXU/kg feed. The FEEDAP Panel cannot conclude on the safety of the additive for laying hens and for minor poultry species for laying at the proposed conditions of use. The information provided does not allow to conclude on the safety of the use of ECONASE XT (®) P/L produced by T. reesei CBS 140027 in animal nutrition for the consumers. The use of the additive under assessment in animal nutrition does not raise safety concerns for the environment. ECONASE (®) XT L is non‐irritant to the skin or to the eyes. In absence of data, the FEEDAP Panel cannot conclude on the potential of the solid product to be irritant to skin and eyes and on the potential of the additive in all forms to be a dermal sensitiser. All forms of the additive should be considered as respiratory sensitisers. All forms of the additive are considered efficacious at the minimum recommended levels for the target species. John Wiley and Sons Inc. 2021-04-28 /pmc/articles/PMC8080292/ /pubmed/33959202 http://dx.doi.org/10.2903/j.efsa.2021.6536 Text en © 2021 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Fašmon Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Cocconcelli, Pier Sandro
Glandorf, Boet
Gropp, Jűrgen
Prieto Maradona, Miguel
Rychen, Guido
Saarela, Maria
Anguita, Montserrat
Galobart, Jaume
Pettenati, Elisa
Tarrés‐Call, Jordi
Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase (ECONASE (®) XT) produced by Trichoderma reesei CBS 140027 as a feed additive for piglets (weaned), pigs for fattening, chickens for fattening, chickens reared for laying, laying hens, turkeys for fattening, turkeys reared for breeding and minor poultry species (Roal Oy)
title Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase (ECONASE (®) XT) produced by Trichoderma reesei CBS 140027 as a feed additive for piglets (weaned), pigs for fattening, chickens for fattening, chickens reared for laying, laying hens, turkeys for fattening, turkeys reared for breeding and minor poultry species (Roal Oy)
title_full Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase (ECONASE (®) XT) produced by Trichoderma reesei CBS 140027 as a feed additive for piglets (weaned), pigs for fattening, chickens for fattening, chickens reared for laying, laying hens, turkeys for fattening, turkeys reared for breeding and minor poultry species (Roal Oy)
title_fullStr Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase (ECONASE (®) XT) produced by Trichoderma reesei CBS 140027 as a feed additive for piglets (weaned), pigs for fattening, chickens for fattening, chickens reared for laying, laying hens, turkeys for fattening, turkeys reared for breeding and minor poultry species (Roal Oy)
title_full_unstemmed Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase (ECONASE (®) XT) produced by Trichoderma reesei CBS 140027 as a feed additive for piglets (weaned), pigs for fattening, chickens for fattening, chickens reared for laying, laying hens, turkeys for fattening, turkeys reared for breeding and minor poultry species (Roal Oy)
title_short Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase (ECONASE (®) XT) produced by Trichoderma reesei CBS 140027 as a feed additive for piglets (weaned), pigs for fattening, chickens for fattening, chickens reared for laying, laying hens, turkeys for fattening, turkeys reared for breeding and minor poultry species (Roal Oy)
title_sort safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase (econase (®) xt) produced by trichoderma reesei cbs 140027 as a feed additive for piglets (weaned), pigs for fattening, chickens for fattening, chickens reared for laying, laying hens, turkeys for fattening, turkeys reared for breeding and minor poultry species (roal oy)
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080292/
https://www.ncbi.nlm.nih.gov/pubmed/33959202
http://dx.doi.org/10.2903/j.efsa.2021.6536
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AT mayobaltasar safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT pechovaalena safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT petkovamariana safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT ramosfernando safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT sanzyolanda safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT villarobertoedoardo safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT woutersenruud safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT cocconcellipiersandro safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT glandorfboet safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT groppjurgen safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT prietomaradonamiguel safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT rychenguido safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT saarelamaria safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT anguitamontserrat safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT galobartjaume safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT pettenatielisa safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor
AT tarrescalljordi safetyandefficacyofafeedadditiveconsistingofendo14bxylanaseeconasextproducedbytrichodermareeseicbs140027asafeedadditiveforpigletsweanedpigsforfatteningchickensforfatteningchickensrearedforlayinglayinghensturkeysforfatteningturkeysrearedforbreedingandminor