A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis

A new kind of photolabile protecting group (PLPG) for carboxyl moieties was designed and synthesized as the linker between resin and peptide. This group can be used for the protection of amino acid carboxyl groups. The peptide was synthesized on Nph (2‐hydroxy‐3‐(2‐nitrophenyl)‐heptanoic acid)‐deriv...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Hongpeng, Peng, Tao, Wen, Xiaoxue, Chen, Tingting, Sun, Yunbo, Liu, Shuchen, Wang, Gang, Zhang, Shouguo, Wang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080293/
https://www.ncbi.nlm.nih.gov/pubmed/33908701
http://dx.doi.org/10.1002/open.202000324
_version_ 1783685396381564928
author Yang, Hongpeng
Peng, Tao
Wen, Xiaoxue
Chen, Tingting
Sun, Yunbo
Liu, Shuchen
Wang, Gang
Zhang, Shouguo
Wang, Lin
author_facet Yang, Hongpeng
Peng, Tao
Wen, Xiaoxue
Chen, Tingting
Sun, Yunbo
Liu, Shuchen
Wang, Gang
Zhang, Shouguo
Wang, Lin
author_sort Yang, Hongpeng
collection PubMed
description A new kind of photolabile protecting group (PLPG) for carboxyl moieties was designed and synthesized as the linker between resin and peptide. This group can be used for the protection of amino acid carboxyl groups. The peptide was synthesized on Nph (2‐hydroxy‐3‐(2‐nitrophenyl)‐heptanoic acid)‐derivatized resins and could be cleaved under UV exposure, thus avoiding the necessity for harsh acid‐mediated resin cleavage. The PLPG has been successfully used for solid‐phase synthesis of peptides.
format Online
Article
Text
id pubmed-8080293
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-80802932021-05-05 A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis Yang, Hongpeng Peng, Tao Wen, Xiaoxue Chen, Tingting Sun, Yunbo Liu, Shuchen Wang, Gang Zhang, Shouguo Wang, Lin ChemistryOpen Full Papers A new kind of photolabile protecting group (PLPG) for carboxyl moieties was designed and synthesized as the linker between resin and peptide. This group can be used for the protection of amino acid carboxyl groups. The peptide was synthesized on Nph (2‐hydroxy‐3‐(2‐nitrophenyl)‐heptanoic acid)‐derivatized resins and could be cleaved under UV exposure, thus avoiding the necessity for harsh acid‐mediated resin cleavage. The PLPG has been successfully used for solid‐phase synthesis of peptides. John Wiley and Sons Inc. 2021-04-28 /pmc/articles/PMC8080293/ /pubmed/33908701 http://dx.doi.org/10.1002/open.202000324 Text en © 2021 The Authors. Published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Full Papers
Yang, Hongpeng
Peng, Tao
Wen, Xiaoxue
Chen, Tingting
Sun, Yunbo
Liu, Shuchen
Wang, Gang
Zhang, Shouguo
Wang, Lin
A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis
title A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis
title_full A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis
title_fullStr A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis
title_full_unstemmed A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis
title_short A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis
title_sort photolabile carboxyl protecting group for solid phase peptide synthesis
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080293/
https://www.ncbi.nlm.nih.gov/pubmed/33908701
http://dx.doi.org/10.1002/open.202000324
work_keys_str_mv AT yanghongpeng aphotolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT pengtao aphotolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT wenxiaoxue aphotolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT chentingting aphotolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT sunyunbo aphotolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT liushuchen aphotolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT wanggang aphotolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT zhangshouguo aphotolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT wanglin aphotolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT yanghongpeng photolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT pengtao photolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT wenxiaoxue photolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT chentingting photolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT sunyunbo photolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT liushuchen photolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT wanggang photolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT zhangshouguo photolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis
AT wanglin photolabilecarboxylprotectinggroupforsolidphasepeptidesynthesis

Ejemplares similares