Cargando…

Prognostic value of SH3PXD2B (Tks4) in human hepatocellular carcinoma: a combined multi-omics and experimental study

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common and fatal cancers worldwide. HCC invasion and metastasis are crucial for its poor prognosis. SH3PXD2B is a scaffold protein and critical for intravascular and extravascular invasion and metastasis of various types of tumors. Howeve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kui, Xiang, Wang, Yan, Zhang, Cheng, Li, Hai, Li, Qingfeng, Ke, Yang, Wang, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080318/ https://www.ncbi.nlm.nih.gov/pubmed/33906640 http://dx.doi.org/10.1186/s12920-021-00963-6

Ejemplares similares

Genetic Disruption of the Sh3pxd2a Gene Reveals an Essential Role in Mouse Development and the Existence of a Novel Isoform of Tks5
por: Cejudo-Martin, Pilar, et al.
Publicado: (2014)

Up-Regulated Expression and Aberrant DNA Methylation of LEP and SH3PXD2A in Pre-Eclampsia
por: Xiang, Yuqian, et al.
Publicado: (2013)

Tks5 SH3 domains exhibit differential effects on invadopodia development
por: Daly, Christina, et al.
Publicado: (2020)

Sh3pxd2b Mice Are a Model for Craniofacial Dysmorphology and Otitis Media
por: Yang, Bin, et al.
Publicado: (2011)

The Homolog of the Five SH3-Domain Protein (HOFI/SH3PXD2B) Regulates Lamellipodia Formation and Cell Spreading
por: Lányi, Árpád, et al.
Publicado: (2011)

TKS—The gentle molder
por: Tuli, Surendar Mohan
Publicado: (2008)

The Role of the Disrupted Podosome Adaptor Protein (SH3PXD2B) in Frank–Ter Haar Syndrome
por: Massadeh, Salam, et al.
Publicado: (2022)

Multi-omics analysis reveals prognostic value of tumor mutation burden in hepatocellular carcinoma
por: Xu, Qianhui, et al.
Publicado: (2021)

Localization of SH3PXD2B in human eyes and detection of rare variants in patients with anterior segment diseases and glaucoma
por: Mao, Mao, et al.
Publicado: (2012)

The SH3PXD2A-HTRA1 fusion transcript is extremely rare in Norwegian sporadic vestibular schwannoma patients
por: Taule-Sivertsen, Peter, et al.
Publicado: (2021)

Association of lncRNA SH3PXD2A-AS1 with preeclampsia and its function in invasion and migration of placental trophoblast cells
por: Chen, Qian, et al.
Publicado: (2020)

Planning by design (PxD)-based systematic methodologies
por: Butuner, Hakan
Publicado: (2017)

Long noncoding RNA SH3PXD2A-AS1 promotes NSCLC proliferation and accelerates cell cycle progression by interacting with DHX9
por: Zhou, Yeqing, et al.
Publicado: (2022)

Long noncoding RNA SH3PXD2A-AS1 promotes colorectal cancer progression by regulating p53-mediated gene transcription
por: Hou, Pingfu, et al.
Publicado: (2021)

High expression of the long noncoding RNA SH3PXD2A-AS1 is associated with poor prognosis in patients with esophageal squamous cell carcinoma
por: Luo, Qiuli, et al.
Publicado: (2020)

Analysis of Tks4 Knockout Mice Suggests a Role for Tks4 in Adipose Tissue Homeostasis in the Context of Beigeing
por: Vas, Virag, et al.
Publicado: (2019)

Correction: Long noncoding RNA SH3PXD2A-AS1 promotes NSCLC proliferation and accelerates cell cycle progression by interacting with DHX9
por: Zhou, Yeqing, et al.
Publicado: (2023)

The novel zebrafish model pretzel demonstrates a central role for SH3PXD2B in defective collagen remodelling and fibrosis in Frank-Ter Haar syndrome
por: de Vos, Ivo J. H. M., et al.
Publicado: (2020)

The Role of TKS5 in Chromosome Stability and Bladder Cancer Progression
por: Wang, Wenya, et al.
Publicado: (2022)

Advances in Understanding TKS4 and TKS5: Molecular Scaffolds Regulating Cellular Processes from Podosome and Invadopodium Formation to Differentiation and Tissue Homeostasis
por: Kudlik, Gyöngyi, et al.
Publicado: (2020)

Extracellular Vesicles Derived circSH3PXD2A Inhibits Chemoresistance of Small Cell Lung Cancer by miR-375-3p/YAP1
por: Chao, Fengmei, et al.
Publicado: (2023)

A diagnostic circulating miRNA signature as orchestrator of cell invasion via TKS4/TKS5/EFHD2 modulation in human gliomas
por: Díaz Méndez, Ana Belén, et al.
Publicado: (2023)

Pan-cancer analysis from multi-omics data reveals AAMP as an unfavourable prognostic marker
por: Wang, Yang, et al.
Publicado: (2023)

Utility of a Histone Deacetylase Inhibitor (PXD101) for Thyroid Cancer Treatment
por: Lin, Shu-Fu, et al.
Publicado: (2013)

Experimental supporting data on TKS5 and Cortactin expression and localization in human pancreatic cancer cells and tumors
por: Chen, Yu-Chuan, et al.
Publicado: (2018)

Dystroglycan, Tks5 and Src Mediated Assembly of Podosomes in Myoblasts
por: Thompson, Oliver, et al.
Publicado: (2008)

Possible role of IRTKS in Tks5-driven osteoclast fusion
por: Oikawa, Tsukasa, et al.
Publicado: (2012)

Significance of the Tks4 scaffold protein in bone tissue homeostasis
por: Vas, Virag, et al.
Publicado: (2019)

A Systematic Comparison of the Anti-Tumoural Activity and Toxicity of the Three Adv-TKs
por: Gao, Qinglei, et al.
Publicado: (2014)

Multi-omics analysis of expression and prognostic value of NSUN members in prostate cancer
por: Sun, Guangyu, et al.
Publicado: (2022)

Fission Yeast Pxd1 Promotes Proper DNA Repair by Activating Rad16(XPF) and Inhibiting Dna2
por: Zhang, Jia-Min, et al.
Publicado: (2014)

Peroxisomes move by hitchhiking on early endosomes using the novel linker protein PxdA
por: Salogiannis, John, et al.
Publicado: (2016)

PxdA interacts with the DipA phosphatase to regulate peroxisome hitchhiking on early endosomes
por: Salogiannis, John, et al.
Publicado: (2021)

Identification of multi-omics biomarkers and construction of the novel prognostic model for hepatocellular carcinoma
por: Liu, Xiao, et al.
Publicado: (2022)

Correction: A Systematic Comparison of the Anti-Tumoural Activity and Toxicity of the Three Adv-TKs
por: Gao, Qinglei, et al.
Publicado: (2016)

Tir Is Essential for the Recruitment of Tks5 to Enteropathogenic Escherichia coli Pedestals
por: Jensen, Helene H., et al.
Publicado: (2015)

The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma
por: Iizuka, Shinji, et al.
Publicado: (2016)

Characterization of the Intramolecular Interactions and Regulatory Mechanisms of the Scaffold Protein Tks4
por: Merő, Balázs, et al.
Publicado: (2021)

Development and validation of multi-omic prognostic signature of anoikis-related genes in liver hepatocellular carcinoma
por: Ding,, Dongxiao, et al.
Publicado: (2023)

Mannose-Binding Lectin 2 as a Potential Therapeutic Target for Hepatocellular Carcinoma: Multi-Omics Analysis and Experimental Validation
por: Liao, Hangyu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jvf3tgl0g3l18ek8fml72rkghc