Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice

BACKGROUND: Genes with multiple co-active promoters appear common in brain, yet little is known about functional requirements for these potentially redundant genomic regulatory elements. SCN1A, which encodes the Na(V)1.1 sodium channel alpha subunit, is one such gene with two co-active promoters. Mu...

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Detalles Bibliográficos
Autores principales: Haigh, Jessica L., Adhikari, Anna, Copping, Nycole A., Stradleigh, Tyler, Wade, A. Ayanna, Catta-Preta, Rinaldo, Su-Feher, Linda, Zdilar, Iva, Morse, Sarah, Fenton, Timothy A., Nguyen, Anh, Quintero, Diana, Agezew, Samrawit, Sramek, Michael, Kreun, Ellie J., Carter, Jasmine, Gompers, Andrea, Lambert, Jason T., Canales, Cesar P., Pennacchio, Len A., Visel, Axel, Dickel, Diane E., Silverman, Jill L., Nord, Alex S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080386/
https://www.ncbi.nlm.nih.gov/pubmed/33910599
http://dx.doi.org/10.1186/s13073-021-00884-0

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