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Dynamic changes and prevalence of SARS-CoV-2 IgG/IgM antibodies: Analysis of multiple factors
OBJECTIVE: To investigate the dynamic characteristics of serological antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is of much current significance. METHODS: The dynamic changes and prevalence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080494/ https://www.ncbi.nlm.nih.gov/pubmed/33932603 http://dx.doi.org/10.1016/j.ijid.2021.04.078 |
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author | Luo, Chunhua Liu, Min Li, Qianyuan Zheng, Xiaoling Ai, Wen Gong, Feng Fan, Jinhong Liu, Shaowei Wang, Xi Luo, Jun |
author_facet | Luo, Chunhua Liu, Min Li, Qianyuan Zheng, Xiaoling Ai, Wen Gong, Feng Fan, Jinhong Liu, Shaowei Wang, Xi Luo, Jun |
author_sort | Luo, Chunhua |
collection | PubMed |
description | OBJECTIVE: To investigate the dynamic characteristics of serological antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is of much current significance. METHODS: The dynamic changes and prevalence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against SARS-CoV-2 were assessed from the time of symptom onset up to 210 days. Antibodies were detected using a chemiluminescence immunoassay. RESULTS: The average titers and IgG/IgM positivity rates reached a peak within 30 days of symptom onset and then began to decline continuously. Between 180 and 210 days following symptom onset, the titers of IgG and IgM were 43.1 ± 27.0 AU/mL and 4.4 ± 5.2 AU/mL, respectively, while the respective positivity rates were 84.3% and 12.0%. Further statistical analyses revealed that the dynamic changes and prevalence of the SARS-CoV-2 IgG/IgM antibodies were related to age and disease severity, but not to sex. The dynamic changes and the prevalence were similar for both the IgM and the IgG antibodies. Even so, there was a more rapid rate of decline for the IgM antibodies. It was found that an IgG level of 16.33 ± 3.15 AU/mL may represent a threshold value that should act as an alert, as it may indicate that the IgG level will become undetectable within the next 30–60 days. CONCLUSION: The results provide important information concerning COVID-19 and may be of relevance for diagnosis, treatment, and vaccine development. |
format | Online Article Text |
id | pubmed-8080494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80804942021-04-29 Dynamic changes and prevalence of SARS-CoV-2 IgG/IgM antibodies: Analysis of multiple factors Luo, Chunhua Liu, Min Li, Qianyuan Zheng, Xiaoling Ai, Wen Gong, Feng Fan, Jinhong Liu, Shaowei Wang, Xi Luo, Jun Int J Infect Dis Article OBJECTIVE: To investigate the dynamic characteristics of serological antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is of much current significance. METHODS: The dynamic changes and prevalence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against SARS-CoV-2 were assessed from the time of symptom onset up to 210 days. Antibodies were detected using a chemiluminescence immunoassay. RESULTS: The average titers and IgG/IgM positivity rates reached a peak within 30 days of symptom onset and then began to decline continuously. Between 180 and 210 days following symptom onset, the titers of IgG and IgM were 43.1 ± 27.0 AU/mL and 4.4 ± 5.2 AU/mL, respectively, while the respective positivity rates were 84.3% and 12.0%. Further statistical analyses revealed that the dynamic changes and prevalence of the SARS-CoV-2 IgG/IgM antibodies were related to age and disease severity, but not to sex. The dynamic changes and the prevalence were similar for both the IgM and the IgG antibodies. Even so, there was a more rapid rate of decline for the IgM antibodies. It was found that an IgG level of 16.33 ± 3.15 AU/mL may represent a threshold value that should act as an alert, as it may indicate that the IgG level will become undetectable within the next 30–60 days. CONCLUSION: The results provide important information concerning COVID-19 and may be of relevance for diagnosis, treatment, and vaccine development. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-07 2021-04-28 /pmc/articles/PMC8080494/ /pubmed/33932603 http://dx.doi.org/10.1016/j.ijid.2021.04.078 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Luo, Chunhua Liu, Min Li, Qianyuan Zheng, Xiaoling Ai, Wen Gong, Feng Fan, Jinhong Liu, Shaowei Wang, Xi Luo, Jun Dynamic changes and prevalence of SARS-CoV-2 IgG/IgM antibodies: Analysis of multiple factors |
title | Dynamic changes and prevalence of SARS-CoV-2 IgG/IgM antibodies: Analysis of multiple factors |
title_full | Dynamic changes and prevalence of SARS-CoV-2 IgG/IgM antibodies: Analysis of multiple factors |
title_fullStr | Dynamic changes and prevalence of SARS-CoV-2 IgG/IgM antibodies: Analysis of multiple factors |
title_full_unstemmed | Dynamic changes and prevalence of SARS-CoV-2 IgG/IgM antibodies: Analysis of multiple factors |
title_short | Dynamic changes and prevalence of SARS-CoV-2 IgG/IgM antibodies: Analysis of multiple factors |
title_sort | dynamic changes and prevalence of sars-cov-2 igg/igm antibodies: analysis of multiple factors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080494/ https://www.ncbi.nlm.nih.gov/pubmed/33932603 http://dx.doi.org/10.1016/j.ijid.2021.04.078 |
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