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Nrf2 activation putatively mediates clinical benefits of low-dose radiotherapy in COVID-19 pneumonia and acute respiratory distress syndrome (ARDS): Novel mechanistic considerations

Novel mechanistic insights are discussed herein that link a single, nontoxic, low-dose radiotherapy (LDRT) treatment (0.5–1.0 Gy) to (1) beneficial subcellular effects mediated by the activation of nuclear factor erythroid 2-related transcription factor (Nrf2) and to (2) favorable clinical outcomes...

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Detalles Bibliográficos
Autores principales:	Calabrese, Edward J., Kozumbo, Walter J., Kapoor, Rachna, Dhawan, Gaurav, Lara, Pedro C., Giordano, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080499/ https://www.ncbi.nlm.nih.gov/pubmed/33932453 http://dx.doi.org/10.1016/j.radonc.2021.04.015

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