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Discovery of a novel RORγ antagonist with skin-restricted exposure for topical treatment of mild to moderate psoriasis

Clinical success of IL-17/IL-23 pathway biologics for the treatment of moderate to severe psoriasis suggests that targeting RORγt, a master regulator for the proliferation and function of Th17 cells, could be an effective alternative. However, oral RORγ antagonists (VTP43742, TAK828) with high syste...

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Detalles Bibliográficos
Autores principales:	Liu, Suxing, Liu, Dong, Shen, Ru, Li, Di, Hu, Qiyue, Yan, Yinfa, Sun, Jiakang, Zhang, Fengqi, Wan, Hong, Dong, Ping, Feng, Jun, Zhang, Rumin, Li, Jing, Zhang, Lianshan, Tao, Weikang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080595/ https://www.ncbi.nlm.nih.gov/pubmed/33911101 http://dx.doi.org/10.1038/s41598-021-88492-1

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