Cargando…

Dexmedetomidine promotes the progression of hepatocellular carcinoma through hepatic stellate cell activation

Dexmedetomidine (DEX) is an anesthetic that is widely used in the clinic, and it has been reported to exhibit paradoxical effects in the progression of multiple solid tumors. In this study, we sought to explore the mechanism by which DEX regulates hepatocellular carcinoma (HCC) progression underlyin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Peng, Luo, Xiaojun, Dai, Guanqi, Jiang, Yuchuan, Luo, Yue, Peng, Shuang, Wang, Hao, Xie, Penghui, Qu, Chen, Lin, Wenyu, Hong, Jian, Ning, Xue, Li, Aimin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080602/ https://www.ncbi.nlm.nih.gov/pubmed/32632241 http://dx.doi.org/10.1038/s12276-020-0461-6

Ejemplares similares

Inflammatory microenvironment of fibrotic liver promotes hepatocellular carcinoma growth, metastasis and sorafenib resistance through STAT3 activation
por: Jiang, Yuchuan, et al.
Publicado: (2021)

Identification of Gene Signatures for Diagnosis and Prognosis of Hepatocellular Carcinomas Patients at Early Stage
por: Gan, Xiaoning, et al.
Publicado: (2020)

Hepatic Stellate Cell Modulates the Immune Microenvironment in the Progression of Hepatocellular Carcinoma
por: Wang, Pei-Wen, et al.
Publicado: (2022)

Hepatic stellate cell activation and senescence induced by intrahepatic microbiota disturbances drive progression of liver cirrhosis toward hepatocellular carcinoma
por: Liu, Boyuan, et al.
Publicado: (2022)

CCN1/Cyr61 enhances the function of hepatic stellate cells in promoting the progression of hepatocellular carcinoma
por: Li, Zhi-Qiang, et al.
Publicado: (2018)

Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin
por: Mogler, Carolin, et al.
Publicado: (2017)

HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma
por: Chen, Qi-tao, et al.
Publicado: (2022)

β-arrestin2 regulating β2-adrenergic receptor signaling in hepatic stellate cells contributes to hepatocellular carcinoma progression
por: Li, Xiu-Qin, et al.
Publicado: (2021)

Secretome of senescent hepatic stellate cells favors malignant transformation from nonalcoholic steatohepatitis-fibrotic progression to hepatocellular carcinoma
por: Zhou, Yuan, et al.
Publicado: (2023)

Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2
por: Song, Zhenghui, et al.
Publicado: (2022)

Cancer Stem Cell and Hepatic Stellate Cells in Hepatocellular Carcinoma
por: Quiroz Reyes, Adriana G., et al.
Publicado: (2023)

Hepatitis B Virus Promotes Hepatocellular Carcinoma Progression Synergistically With Hepatic Stellate Cells via Facilitating the Expression and Secretion of ENPP2
por: Deng, Wanyu, et al.
Publicado: (2021)

Stimulated hepatic stellate cell promotes progression of hepatocellular carcinoma due to protein kinase R activation
por: Imai, Yusuke, et al.
Publicado: (2019)

Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma
por: Seitz, Tatjana, et al.
Publicado: (2020)

Nuclear GAPDH is vital for hypoxia-induced hepatic stellate cell apoptosis and is indicative of aggressive hepatocellular carcinoma behavior
por: Gong, Yihang, et al.
Publicado: (2019)

Role of PDLIM1 in hepatic stellate cell activation and liver fibrosis progression
por: Ye, Bingyu, et al.
Publicado: (2023)

Activated hepatic stellate cells promote angiogenesis via interleukin-8 in hepatocellular carcinoma
por: Zhu, Bing, et al.
Publicado: (2015)

Role of hepatic stellate cells in liver ischemia-reperfusion injury
por: Peng, Yuming, et al.
Publicado: (2022)

The potential of mecciRNA in hepatic stellate cell to regulate progression of nonalcoholic hepatitis
por: Liu, Boqiang, et al.
Publicado: (2022)

MIRLET7BHG promotes hepatocellular carcinoma progression by activating hepatic stellate cells through exosomal SMO to trigger Hedgehog pathway
por: Xia, Yunhong, et al.
Publicado: (2021)

Human umbilical cord mesenchymal stem cells inhibit proliferation of hepatic stellate cells in vitro
por: Zhang, Li-Ting, et al.
Publicado: (2018)

Expression of Cyclin E1 in hepatic stellate cells is critical for the induction and progression of liver fibrosis and hepatocellular carcinoma in mice
por: Otto, Julia, et al.
Publicado: (2023)

Clinical significance and gene expression study of human hepatic stellate cells in HBV related-hepatocellular carcinoma
por: Liao, Rui, et al.
Publicado: (2013)

The role of hepatic stellate cells in the regulation of T-cell function and the promotion of hepatocellular carcinoma
por: ZHAO, WENXIU, et al.
Publicado: (2012)

Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma
por: Yang, Qiqi, et al.
Publicado: (2017)

Crosstalk between hepatic stellate cells and tumor cells in the development of hepatocellular carcinoma
por: Ma, Ya-Nan, et al.
Publicado: (2021)

Inhibition of Hepatic Stellate Cell Activation Suppresses Tumorigenicity of Hepatocellular Carcinoma in Mice
por: Kang, Min-Jung, et al.
Publicado: (2021)

GJA1 promotes hepatocellular carcinoma progression by mediating TGF-β-induced activation and the epithelial–mesenchymal transition of hepatic stellate cells
por: Niu, Gengming, et al.
Publicado: (2021)

Profiles of messenger RNAs and MicroRNAs in hypoxia-induced hepatic stellate cells
por: Zhang, Liting, et al.
Publicado: (2021)

Hepatic Stellate Cells and Hepatocarcinogenesis
por: Barry, Anna E., et al.
Publicado: (2020)

Neuropilin-1 promotes primary liver cancer progression by potentiating the activity of hepatic stellate cells
por: Xu, Zhi-Chao, et al.
Publicado: (2018)

Periostin involved in the activated hepatic stellate cells-induced progression of residual hepatocellular carcinoma after sublethal heat treatment: its role and potential for therapeutic inhibition
por: Zhang, Rui, et al.
Publicado: (2018)

Hepatic Stellate Cells Secreted Hepatocyte Growth Factor Contributes to the Chemoresistance of Hepatocellular Carcinoma
por: Yu, Guofeng, et al.
Publicado: (2013)

Bevacizumab Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells
por: Huang, Yangqing, et al.
Publicado: (2013)

Activated Hepatic Stellate Cells (HSCs) Exert Immunosuppressive Effects in Hepatocellular Carcinoma by Producing Complement C3
por: Xu, Yaping, et al.
Publicado: (2020)

Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis
por: Zhao, Xue-Ke, et al.
Publicado: (2017)

MicroRNA-194 inactivates hepatic stellate cells and alleviates liver fibrosis by inhibiting AKT2
por: Wu, Jun-Cheng, et al.
Publicado: (2019)

Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression
por: Wijayasiri, Pramudi, et al.
Publicado: (2022)

Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function?
por: Herrmann, Jens, et al.
Publicado: (2007)

Remodeling of hepatic stellate cells orchestrated the stroma-derived oxaliplatin-resistance through CCN3 paracrine in hepatocellular carcinoma
por: Liao, Xia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_91vqg1tnp1lds5i5h6kajatf2q