Cargando…

The risk of developing a meningioma during and after pregnancy

Pregnancy has been associated with diagnosis or growth of meningiomas in several case reports, which has led to the hypothesis that pregnancy may be a risk factor for meningiomas. The aim of this study was to test this hypothesis in a large population-based cohort study. Women born in Sweden 1958–20...

Descripción completa

Detalles Bibliográficos
Autores principales: Pettersson-Segerlind, Jenny, Mathiesen, Tiit, Elmi-Terander, Adrian, Edström, Erik, Talbäck, Mats, Feychting, Maria, Tettamanti, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080659/
https://www.ncbi.nlm.nih.gov/pubmed/33911184
http://dx.doi.org/10.1038/s41598-021-88742-2
_version_ 1783685479870234624
author Pettersson-Segerlind, Jenny
Mathiesen, Tiit
Elmi-Terander, Adrian
Edström, Erik
Talbäck, Mats
Feychting, Maria
Tettamanti, Giorgio
author_facet Pettersson-Segerlind, Jenny
Mathiesen, Tiit
Elmi-Terander, Adrian
Edström, Erik
Talbäck, Mats
Feychting, Maria
Tettamanti, Giorgio
author_sort Pettersson-Segerlind, Jenny
collection PubMed
description Pregnancy has been associated with diagnosis or growth of meningiomas in several case reports, which has led to the hypothesis that pregnancy may be a risk factor for meningiomas. The aim of this study was to test this hypothesis in a large population-based cohort study. Women born in Sweden 1958–2000 (N = 2,204,126) were identified and matched with the Medical Birth Register and the Cancer Register. The expected number of meningioma cases and risk ratios were calculated for parous and nulliparous women and compared to the observed number of cases. Compared to parous women, meningiomas were more common among nulliparous (SIR = 1.73; 95% CI 1.52–1.95). The number of meningioma cases detected during pregnancy was lower than the expected (SIR = 0.40; 95% CI 0.20–0.72). Moreover, no increased risk was found in the first-year post-partum (SIR = 1.04; 95% CI 0.74–1.41). Contrary to our hypothesis, there was no increased risk for diagnosing a meningioma during pregnancy or 1-year post-partum. A lower detection rate during pregnancy, may reflect under-utilization of diagnostic procedures, but the actual number of meningiomas was homogenously lower among parous than nulliparous women throughout the study period, indicating that pregnancy is not a risk factor for meningioma.
format Online
Article
Text
id pubmed-8080659
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-80806592021-04-30 The risk of developing a meningioma during and after pregnancy Pettersson-Segerlind, Jenny Mathiesen, Tiit Elmi-Terander, Adrian Edström, Erik Talbäck, Mats Feychting, Maria Tettamanti, Giorgio Sci Rep Article Pregnancy has been associated with diagnosis or growth of meningiomas in several case reports, which has led to the hypothesis that pregnancy may be a risk factor for meningiomas. The aim of this study was to test this hypothesis in a large population-based cohort study. Women born in Sweden 1958–2000 (N = 2,204,126) were identified and matched with the Medical Birth Register and the Cancer Register. The expected number of meningioma cases and risk ratios were calculated for parous and nulliparous women and compared to the observed number of cases. Compared to parous women, meningiomas were more common among nulliparous (SIR = 1.73; 95% CI 1.52–1.95). The number of meningioma cases detected during pregnancy was lower than the expected (SIR = 0.40; 95% CI 0.20–0.72). Moreover, no increased risk was found in the first-year post-partum (SIR = 1.04; 95% CI 0.74–1.41). Contrary to our hypothesis, there was no increased risk for diagnosing a meningioma during pregnancy or 1-year post-partum. A lower detection rate during pregnancy, may reflect under-utilization of diagnostic procedures, but the actual number of meningiomas was homogenously lower among parous than nulliparous women throughout the study period, indicating that pregnancy is not a risk factor for meningioma. Nature Publishing Group UK 2021-04-28 /pmc/articles/PMC8080659/ /pubmed/33911184 http://dx.doi.org/10.1038/s41598-021-88742-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Pettersson-Segerlind, Jenny
Mathiesen, Tiit
Elmi-Terander, Adrian
Edström, Erik
Talbäck, Mats
Feychting, Maria
Tettamanti, Giorgio
The risk of developing a meningioma during and after pregnancy
title The risk of developing a meningioma during and after pregnancy
title_full The risk of developing a meningioma during and after pregnancy
title_fullStr The risk of developing a meningioma during and after pregnancy
title_full_unstemmed The risk of developing a meningioma during and after pregnancy
title_short The risk of developing a meningioma during and after pregnancy
title_sort risk of developing a meningioma during and after pregnancy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080659/
https://www.ncbi.nlm.nih.gov/pubmed/33911184
http://dx.doi.org/10.1038/s41598-021-88742-2
work_keys_str_mv AT petterssonsegerlindjenny theriskofdevelopingameningiomaduringandafterpregnancy
AT mathiesentiit theriskofdevelopingameningiomaduringandafterpregnancy
AT elmiteranderadrian theriskofdevelopingameningiomaduringandafterpregnancy
AT edstromerik theriskofdevelopingameningiomaduringandafterpregnancy
AT talbackmats theriskofdevelopingameningiomaduringandafterpregnancy
AT feychtingmaria theriskofdevelopingameningiomaduringandafterpregnancy
AT tettamantigiorgio theriskofdevelopingameningiomaduringandafterpregnancy
AT petterssonsegerlindjenny riskofdevelopingameningiomaduringandafterpregnancy
AT mathiesentiit riskofdevelopingameningiomaduringandafterpregnancy
AT elmiteranderadrian riskofdevelopingameningiomaduringandafterpregnancy
AT edstromerik riskofdevelopingameningiomaduringandafterpregnancy
AT talbackmats riskofdevelopingameningiomaduringandafterpregnancy
AT feychtingmaria riskofdevelopingameningiomaduringandafterpregnancy
AT tettamantigiorgio riskofdevelopingameningiomaduringandafterpregnancy