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The risk of developing a meningioma during and after pregnancy
Pregnancy has been associated with diagnosis or growth of meningiomas in several case reports, which has led to the hypothesis that pregnancy may be a risk factor for meningiomas. The aim of this study was to test this hypothesis in a large population-based cohort study. Women born in Sweden 1958–20...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080659/ https://www.ncbi.nlm.nih.gov/pubmed/33911184 http://dx.doi.org/10.1038/s41598-021-88742-2 |
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author | Pettersson-Segerlind, Jenny Mathiesen, Tiit Elmi-Terander, Adrian Edström, Erik Talbäck, Mats Feychting, Maria Tettamanti, Giorgio |
author_facet | Pettersson-Segerlind, Jenny Mathiesen, Tiit Elmi-Terander, Adrian Edström, Erik Talbäck, Mats Feychting, Maria Tettamanti, Giorgio |
author_sort | Pettersson-Segerlind, Jenny |
collection | PubMed |
description | Pregnancy has been associated with diagnosis or growth of meningiomas in several case reports, which has led to the hypothesis that pregnancy may be a risk factor for meningiomas. The aim of this study was to test this hypothesis in a large population-based cohort study. Women born in Sweden 1958–2000 (N = 2,204,126) were identified and matched with the Medical Birth Register and the Cancer Register. The expected number of meningioma cases and risk ratios were calculated for parous and nulliparous women and compared to the observed number of cases. Compared to parous women, meningiomas were more common among nulliparous (SIR = 1.73; 95% CI 1.52–1.95). The number of meningioma cases detected during pregnancy was lower than the expected (SIR = 0.40; 95% CI 0.20–0.72). Moreover, no increased risk was found in the first-year post-partum (SIR = 1.04; 95% CI 0.74–1.41). Contrary to our hypothesis, there was no increased risk for diagnosing a meningioma during pregnancy or 1-year post-partum. A lower detection rate during pregnancy, may reflect under-utilization of diagnostic procedures, but the actual number of meningiomas was homogenously lower among parous than nulliparous women throughout the study period, indicating that pregnancy is not a risk factor for meningioma. |
format | Online Article Text |
id | pubmed-8080659 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80806592021-04-30 The risk of developing a meningioma during and after pregnancy Pettersson-Segerlind, Jenny Mathiesen, Tiit Elmi-Terander, Adrian Edström, Erik Talbäck, Mats Feychting, Maria Tettamanti, Giorgio Sci Rep Article Pregnancy has been associated with diagnosis or growth of meningiomas in several case reports, which has led to the hypothesis that pregnancy may be a risk factor for meningiomas. The aim of this study was to test this hypothesis in a large population-based cohort study. Women born in Sweden 1958–2000 (N = 2,204,126) were identified and matched with the Medical Birth Register and the Cancer Register. The expected number of meningioma cases and risk ratios were calculated for parous and nulliparous women and compared to the observed number of cases. Compared to parous women, meningiomas were more common among nulliparous (SIR = 1.73; 95% CI 1.52–1.95). The number of meningioma cases detected during pregnancy was lower than the expected (SIR = 0.40; 95% CI 0.20–0.72). Moreover, no increased risk was found in the first-year post-partum (SIR = 1.04; 95% CI 0.74–1.41). Contrary to our hypothesis, there was no increased risk for diagnosing a meningioma during pregnancy or 1-year post-partum. A lower detection rate during pregnancy, may reflect under-utilization of diagnostic procedures, but the actual number of meningiomas was homogenously lower among parous than nulliparous women throughout the study period, indicating that pregnancy is not a risk factor for meningioma. Nature Publishing Group UK 2021-04-28 /pmc/articles/PMC8080659/ /pubmed/33911184 http://dx.doi.org/10.1038/s41598-021-88742-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Pettersson-Segerlind, Jenny Mathiesen, Tiit Elmi-Terander, Adrian Edström, Erik Talbäck, Mats Feychting, Maria Tettamanti, Giorgio The risk of developing a meningioma during and after pregnancy |
title | The risk of developing a meningioma during and after pregnancy |
title_full | The risk of developing a meningioma during and after pregnancy |
title_fullStr | The risk of developing a meningioma during and after pregnancy |
title_full_unstemmed | The risk of developing a meningioma during and after pregnancy |
title_short | The risk of developing a meningioma during and after pregnancy |
title_sort | risk of developing a meningioma during and after pregnancy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080659/ https://www.ncbi.nlm.nih.gov/pubmed/33911184 http://dx.doi.org/10.1038/s41598-021-88742-2 |
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